Adrenocorticotropic Hormone (ACTH)

Litaba

• Teko ea adrenocorticotropic hormone (ACTH) ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea ACTH?
• Ho etsahalang nakong ea teko ea ACTH?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea ACTH?
• Litšupiso

Teko ea adrenocorticotropic hormone (ACTH) ke eng?

Teko ena e lekanya boemo ba hormone ea adrenocorticotropic (ACTH) maling. ACTH ke hormone e entsoeng ke tšoelesa ea pituitary, e leng tšoelesa e nyenyane e karolong e ka tlaase ea boko. ACTH e laola tlhahiso ea hormone e ngoe e bitsoang cortisol. Cortisol e entsoe ke litšoelesa tsa adrenal, litšoelesa tse peli tse nyane tse kaholimo ho liphio. Cortisol e bapala karolo ea bohlokoa ho u thusa ho:

• Arabela khatello ea maikutlo
• Loantša tšoaetso
• Laola tsoekere maling
• Boloka khatello ea mali
• Laola metabolism, ts'ebetso ea hore na 'mele oa hau o sebelisa lijo le matla joang

Cortisol e ngata haholo kapa e nyane haholo e ka baka mathata a tebileng a bophelo bo botle.

Mabitso a mang: Adrenocorticotropic hormone test, corticotropin

E sebelisetsoa eng?

Hangata tlhahlobo ea ACTH e etsoa hammoho le teko ea cortisol ho fumana mathata a litšoelesa tsa pituitary kapa adrenal. Tsena li kenyelletsa:

• Cushing’s lefu, lefu leo ​​ho lona tšoelesa ea adrenal e etsang cortisol e ngata haholo. E kanna ea bakoa ke hlahala pong ea tšoelesa ea pituitary kapa ts'ebeliso ea meriana ea steroid. Li-steroid li sebelisetsoa ho phekola ho ruruha, empa li ka ba le litla-morao tse bakang maemo a cortisol.
• Lefu la Cushing, mofuta oa Cushing’s syndrome. Bothateng bona, lesela la pituitary le etsa ACTH e ngata haholo. Hangata e bakoa ke hlahala e se nang mofetše ea tšoelesa ea pituitary.
• Lefu la Addison, boemo boo tšoelesa ea adrenal e sa etse cortisol e lekaneng.
• Boikaketsi, Boloetse boo ho bona tšoelesa ea pituitary e sa lekaneng lihormone tse ling tsa eona.

Hobaneng ha ke hloka tlhahlobo ea ACTH?

U kanna oa hloka tlhahlobo ena haeba u na le matšoao a cortisol e ngata haholo kapa e nyane haholo.

Matšoao a cortisol e ngata haholo a kenyelletsa:

• Boima ba 'mele
• Mafura a mangata mahetleng
• Matšoao a bopinki kapa bopherese (mela) mpeng, liropeng, le / kapa matsoeleng
• Letlalo le tlabolang habonolo
• Ho eketsa moriri oa 'mele
• Bofokoli ba mesifa
• Mokhathala
• Makhopho

Matšoao a cortisol e nyane haholo a kenyelletsa:

• Ho fokotsa boima ba 'mele
• Ho nyekeloa le ho hlatsa
• Letšollo
• Bohloko ba mpeng
• Botsoa
• Ho fifala ha letlalo
• Takatso ea letsoai
• Mokhathala

U kanna ua hloka teko ena haeba u na le matšoao a hypopituitarism. Matšoao a tla fapana ho latela boholo ba lefu lena, empa a ka kenyelletsa tse latelang:

• Ho felloa ke takatso ea lijo
• Linako tse sa tloaelehang tsa ho ilela khoeli le ho hloka thari ho basali
• Ho lahleheloa ke moriri oa 'mele le sefahleho ho banna
• Thobalano e tlase ea banna le basali
• Ho utloahala ho bata
• Ho rota hangata ho feta tloaelo
• Mokhathala

Ho etsahalang nakong ea teko ea ACTH?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

U kanna oa hloka ho itima lijo (u se ke ua ja kapa ua noa) bosiu bo le bong pele ho liteko. Liteko hangata li etsoa hoseng hobane maemo a cortisol a fetoha ho pholletsa le letsatsi.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Liphetho tsa tlhahlobo ea ACTH hangata li bapisoa le litholoana tsa liteko tsa cortisol mme li ka bonts'a e 'ngoe ea tse latelang:

• Maemo a phahameng a ACTH le a phahameng a cortisol: Sena se ka bolela lefu la Cushing.
• Maemo a tlaase a ACTH le a phahameng a cortisol: Sena se ka bolela Cushing's syndrome kapa hlahala ea tšoelesa ea adrenal.
• Maemo a phahameng a ACTH le a tlase a cortisol: Sena se ka bolela lefu la Addison.
• Maemo a tlase a ACTH le maemo a tlase a cortisol. Sena se ka bolela hypopituitarism.

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea ACTH?

Ka linako tse ling tlhahlobo e bitsoang ACTH stimulation test e etsoa ho fapana le tlhahlobo ea ACTH ho fumana lefu la Addison le hypopituitarism. Teko ea ho hlohlelletsa ACTH ke teko ea mali e metha maemo a cortisol pele le kamora hore o fumane ente ea ACTH.

Litšupiso

1. Family doctor.org [Inthanete]. Leawood (KS): Sekolo sa Amerika sa Lingaka tsa Malapa; c2019. Mokhoa oa ho emisa meriana ea Steroid ka polokeho; [e ntlafalitsoeng 2018 Feb 8; ho qotsitsoe 2019 Aug 31]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://familydoctor.org/how-to-stop-steroid-medicines-safely
2. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC; Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Hormone ea Adrenocorticotropic (ACTH); [e ntlafalitsoeng 2019 Jun 5; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/adrenocorticotropic-hormone-acth
3. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC; Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Metabolism; [e ntlafalitsoeng 2017 Jul 10; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/glossary/metabolism
4. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998 --– 2019. Lefu la Addison: Ho hlahloba le ho phekola; 2018 Nov 10 [e qotsitsoeng ka 2019 Aug 27]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/addisons-disease/diagnosis-treatment/drc-20350296
5. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998 --– 2019. Lefu la Addison: Matšoao le lisosa; 2018 Nov 10 [e qotsitsoeng ka 2019 Aug 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
6. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998 --– 2019. Cushing Syndrome: Matšoao le lisosa; 2019 Mots'eanong 30 [e qotsitsoeng 2019 Aug 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310
7. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998-2019. Hypopituitarism: Matšoao le lisosa; 2019 Mots'eanong 18 [e qotsitsoeng 2019 Aug 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/hypopituitarism/symptoms-causes/syc-20351645
8. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng ka la 9 Phato 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
9. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Teko ea mali ea ACTH: Kakaretso; [e ntlafalitsoeng 2019 Aug 27; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/acth-blood-test
10. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Teko ea ts'usumetso ea ACTH: Kakaretso; [e ntlafalitsoeng 2019 Aug 27; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/acth-stimulation-test
11. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Hypopituitarism: Kakaretso; [e ntlafalitsoeng 2019 Aug 27; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/hypopituitarism
12. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2019. Health Encyclopedia: ACTH (Mali); [e qotsitsoeng ka la 9 Phato 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=acth_blood
13. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Tlhahisoleseling ea bophelo bo botle: Adrenocorticotropic Hormone: Liphetho; [e ntlafalitsoeng 2018 Nov 6; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 8]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/adrenocorticotropic-hormone/hw1613.html#hw1639
14. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Tlhahisoleseling ea Bophelo: Adrenocorticotropic Hormone: Kakaretso ea Teko; [e ntlafalitsoeng 2018 Nov 6; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/adrenocorticotropic-hormone/hw1613.html
15. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Tlhahisoleseling ea Bophelo: Hormone ea Adrenocorticotropic: Hobaneng ha e etsoa; [e ntlafalitsoeng 2018 Nov 6; ho qotsitsoe 2019 Aug 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/adrenocorticotropic-hormone/hw1613.html#hw1621

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.