LETSATSI (Mifeprex)

Litaba

• Pele o nka mifepristone,
• Mifepristone e ka baka litla-morao. Bolella ngaka ea hau haeba a mang a matšoao ana a le matla kapa a sa fele:
• Matšoao a ho feta tekano a ka kenyelletsa tse latelang:

Ho tsoa mali ka botšehaling kapa ho sokelang bophelo ka botšehaling ho ka etsahala ha bokhachane bo felisitsoe ke ho senyeheloa ke mpa kapa ke ho ntša mpa ka bongaka kapa kalafo. Ha ho tsejoe hore na ho nka mifepristone ho eketsa kotsi ea hore o tla tsoa mali a mangata haholo. Bolella ngaka ea hau haeba u kile ua ba le mathata a ho tsoa mali, phokolo ea mali (e ka tlase ho palo e tloaelehileng ea lisele tse khubelu tsa mali), kapa haeba u nka li-anticoagulants ('li-thinner tsa mali') tse kang aspirin, apixaban (Eliquis), dabigatran (Pradaxa) , dalteparin (Fragmin), edoxaban (Savaysa). enoxaparin (Lovenox), Fondaparinux (Arixtra), heparin, rivaroxaban powder (Xarelto), kapa warfarin (Coumadin, Jantoven). Haeba ho joalo, mohlomong ngaka ea hau e tla u joetsa hore u se ke ua nka mifepristone. Haeba u e-ba le mali a tsoang ka botšehaling a tsoang ka botšehaling, joalo ka ho inela ka mekotla e meholo e nang le bohloeki bo boholo hora e 'ngoe le e' ngoe lihora tse peli tse sa khaotseng, letsetsa ngaka hang-hang kapa u batle thuso ea bongaka ea tšohanyetso.

Matšoao a tebileng kapa a sokelang bophelo a ka hlaha ha bokhachane bo felisitsoe ke ho senyeheloa ke mpa kapa ke ho ntša mpa ka bongaka kapa kalafo. Palo e fokolang ea bakuli e ile ea hlokahala ka lebaka la tšoaetso eo ba e hlahisitseng kamora hore ba sebelise mifepristone le misoprostol ho emisa boimana ba bona. Ha ho tsejoe hore mifepristone le / kapa misoprostol li bakile tšoaetso kapa lefu lena. Haeba u ba le tšoaetso e tebileng, u kanna oa se be le matšoao a mangata mme matšoao a hau a ka se be matla haholo. U lokela ho letsetsa ngaka ea hau hanghang kapa u fumane kalafo ea tšohanyetso haeba u ka ba le matšoao a latelang: feberu e fetang 100.4 ° F (38 ° C) e tšoarellang nako e fetang lihora tse 4, bohloko bo boholo kapa bonolo sebakeng se ka tlase ho letheka ho bata, ho otla ha pelo kapele, kapa ho akheha.

Hape o lokela ho letsetsa ngaka ea hau hanghang kapa o fumane kalafo ea tšohanyetso haeba o na le matšoao a akaretsang a bokuli joalo ka bofokoli, ho nyekeloa ke pelo, ho hlatsa, letshollo, kapa ho kula ho feta lihora tse 24 kamora ho nka mifepristone leha o sena feberu kapa bohloko. sebakeng se ka tlasa letheka la hao.

Ka lebaka la likotsi tsa mathata a tebileng, mifepristone e fumaneha feela ka lenaneo le thibetsoeng. Lenaneo le neng le bitsoa Lenaneo la Mifeprex Risk Evaluation and Mitigation Strategies (REMS) le se le thehiloe bakeng sa bakuli bohle ba basali ba laetsoeng mifepristone. Ngaka ea hau e tla u fa leseli la moetsi la tlhahisoleseling (Tataiso ea Meriana) hore u le bale pele o qala kalafo ka mifepristone. Hape o tla hloka ho saena tumellano ea mokuli pele o nka mifepristone. Bolella ngaka ea hau haeba u na le lipotso mabapi le kalafo ka mifepristone kapa haeba u sa khone ho latela tataiso ea tumellano ea mokuli. Mifepristone e fumaneha feela litleliniking, liofising tsa bongaka le lipetlele mme ha e fanoe ka li-pharmacy tse rekisang.

Bua le ngaka ea hau 'me u etse qeto ea hore na u letsetse mang le hore na u etse eng maemong a ts'ohanyetso kamora ho nka mifepristone. Bolella ngaka ea hau haeba u sa nahane hore u tla khona ho latela moralo ona kapa ho fumana kalafo ea bongaka kapele maemong a tšohanyetso nakong ea libeke tse peli tsa pele kamora ho nka mifepristone. Tsamaea le motataisi oa hau oa meriana ha u etela kamore ea maemo a tšohanyetso kapa u batla tlhokomelo ea meriana ea tšohanyetso e le hore lingaka tse u phekolang li utloisise hore u ntša mpa.

Boloka linako tsohle le ngaka ea hau. Litumellano tsena lia hlokahala ho netefatsa hore bokhachane ba hau bo felile le hore ha u so be le mathata a tebileng a ho ntša mpa.

Bua le ngaka ea hau ka likotsi tsa ho nka mifepristone.

Mifepristone e sebelisoa hammoho le misoprostol (Cytotec) ho felisa bokhachane ba pelehi. Ho ima pele ho nako ho bolela hore e bile matsatsi a 70 kapa ka tlase ho tloha ha nako ea hau ea ho ilela khoeli e qala. Mifepristone o sehlopheng sa meriana e bitsoang antiprogestational steroids. E sebetsa ka ho thibela tšebetso ea progesterone, ntho eo 'mele oa hau o e etsang ho thusa ho tsoelapele ho ima.

Mifepristone e boetse e fumaneha e le sehlahisoa se seng (Korlym), se sebelisetsoang ho laola hyperglycemia (tsoekere e phahameng maling) ho batho ba nang le mofuta o itseng oa Cushing's Syndrome moo 'mele o etsang hormone ea cortisol e ngata haholo. Monograph ena e fana feela ka leseli mabapi le mifepristone (Mifeprex), e sebelisoang e le mong kapa e kopantsoe le moriana o mong ho felisa bokhachane ba pelehi. Haeba u sebelisa mifepristone ho laola hyperglycemia e bakoang ke Cushing's syndrome, bala monograph e bitsoang mifepristone (Korlym) e ngotsoeng ka sehlahisoa sena.

Mifepristone e tla joalo ka letlapa ho e nka ka molomo. U tla nka letlapa le le leng la mifepristone hang ka letsatsi la pele. Nakong ea lihora tse 24 ho isa ho tse 48 kamora ho noa mifepristone, o tla sebelisa matlapa a mane ka kakaretso ea moriana o mong o bitsoang misoprostol buccally (lipakeng tsa marenene le lerama) ka ho beha matlapa a mabeli ka mokotleng oa lerameng ka metsotso e 30, ebe o metsa tse setseng ka metsi kapa tse ling. mokelikeli. Etsa bonnete ba hore o sebakeng se loketseng ha o nka misoprostol hobane ho tsoa mali ka botšehaling, cramps, ho nyekeloa ke pelo le lets'ollo hangata ho qala nakong ea lihora tse 2 ho isa ho tse 24 kamora ho e noa empa ho ka qala nakong ea lihora tse peli.Ho tsoa mali kapa bosaling ka botšehaling hangata ho nka matsatsi a 9 ho isa ho a 16 empa ho ka nka matsatsi a 30 kapa ho feta. U tlameha ho khutlela ho ngaka ea hau bakeng sa tlhahlobo kapa ultrasound matsatsi a 7 ho isa ho a 14 kamora ho nka mifepristone ho netefatsa hore bokhachane bo felile le ho bona hore na mali a tsoa bokae. Nka mifepristone hantle feela joalokaha e laetsoe.

Mifepristone hape ka linako tse ling e sebelisoa ho felisa boimana ha matsatsi a fetang 70 a fetile ho tloha nakong ea ho qetela ea mosali ea ho ilela khoeli; joalo ka lithibela-pelehi tsa ts'ohanyetso kamora thobalano e sa sireletsoeng ('pilisi ea hoseng-kamora'); ho phekola lihlahala tsa boko, endometriosis (kholo ea lisele tsa popelo kantle ho popelo), kapa fibroids (lihlahala tse se nang kankere ka popelong); kapa ho susumetsa pelehi (ho thusa ho qala tšebetso ea pelehi ho mokhachane). Bua le ngaka ea hau ka likotsi tse ka bang teng tsa ho sebelisa sethethefatsi sena maemong a hau.

Pele o nka mifepristone,

• bolella ngaka ea hau haeba u hanana le mifepristone (hives, rash, ho hlohlona, ​​ho ruruha ha sefahleho, mahlo, molomo, 'metso, matsoho; ho hema ka thata kapa ho metsa); misoprostol (Cytotec, ho Arthrotec); li-prostaglandin tse ling tse kang alprostadil (Caverject, Edex, Muse, tse ling), carboprost tromethamine (Hemabate), dinoprostone (Cervidil, Prepidil, Prostin E2), epoprostenol (Flolan, Veletri), latanoprost (Xalatan), treprostinilod (Orenitram, Orenitram Meriana efe kapa efe, kapa metsoako efe kapa efe ea matlapa a mifepristone. Botsa rakhemisi oa hau kapa u hlahlobe Tataiso ea Meriana bakeng sa lethathamo la metsoako.
• bolella ngaka ea hau haeba u nka li-corticosteroids tse kang beclomethasone (Beconase, QNASL, QVAR), betamethasone (Celestone), budesonide (Entocort, Pulmicort, Uceris), cortisone, dexamethasone, fludrocortisone, flunisolide (Aerospan HFA), Fluticasone , Veramyst, tse ling), hydrocortisone (Cortef, Solu-Cortef, U-Cort, tse ling), methylprednisolone (Medrol, Depo-Medrol), prednisolone (Omnipred, Prelone, ba bang), prednisone (Rayos), le triamcinolone (Kenalog, tse ling) ). Ngaka ea hau e kanna ea u joetsa hore u se ke oa nka mifepristone.
• bolella ngaka ea hau hore na u noa meriana efe e meng eo u e fuoang ke ngaka le eo u sa e fuoeng ke ngaka. Etsa bonnete ba hore o bua ka meriana e thathamisitsoeng karolong ea TEMOSO EA BOHLOKOA le efe kapa efe ea tse latelang: benzodiazepines joalo ka alprazolam (Xanax), diazepam (Diastat, Valium), midazolam, kapa triazolam (Halcion); buspirone; li-block channel tsa calcium tse kang amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, tse ling), felodipine, nifedipine (Adalat, Afeditab CR, Procardia), nisoldipine (Sular), kapa verapamil (Calan, Verelan, in Tarka); carbamazepine (Equetro, Tegretol, Teril, tse ling); chlorpheniramine (antihistamine ka sefuba le lihlahisoa tse batang); meriana e theolang k'holeseterole (li-statin) tse joalo ka atorvastatin (Lipitor, ho Caduet), lovastatin (Altoprev, in Advicor), kapa simvastatin (Simcor, Zocor, Vytorin); clarithromycin (Biaxin, ho Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); erythromycin (EES, Erythrocin, tse ling); haloperidol; furosemide; HIV protease inhibitors e kang indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra, tse ling), kapa saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); methadone (Dolophine, Methadose); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); propranolol (Hemangeol, Inderal, Innopran); quinidine (ka Nuedexta); rifampin (Rifadin, Rimactane, ho Rifamate, ho Rifater); rifabutin (Mycobutin); tacrolimus (Astagraf, Prograf, Protopic, tse ling); tamoxifen (Soltamox); trazodone; kapa vincristine (Marqibo Kit). Ngaka ea hau e kanna ea hloka ho fetola litekanyetso tsa meriana ea hau kapa ho u beha leihlo ka hloko bakeng sa litla-morao.
• bolella ngaka ea hau hore na u sebelisa lihlahisoa life tsa litlama, haholo-holo wort ea St.
• bolella ngaka ea hau haeba u kile ua ba le ectopic pregnancy ('tubal pregnancy' kapa bokhachane ka ntle ho popelo), ho hloleha ha adrenal (mathata a litšoelesa tsa hau tsa adrenal), kapa porphyria (lefu la mali le futsitsoeng le ka bakang mathata a letlalo kapa a methapo ). Ngaka ea hau e kanna ea u joetsa hore u se ke oa nka mifepristone. Hape, bolella ngaka ea hau haeba u kentsoe sesebelisoa sa intrauterine (IUD). E tlameha ho tlosoa pele o nka mifepristone.
• U lokela ho tseba hore ho ka etsahala hore mifepristone e se ke ea emisa ho ima. Ngaka ea hau e tla netefatsa hore na bokhachane ba hau bo felile ha u khutla bakeng sa kopano ea hau ea ho latela kamora ho nka mifepristone. Haeba u ntse u le moimana kamora ho nka mifepristone, ho na le monyetla oa hore ngoana oa hau a ka hlaha a e-na le likoli tsa tlhaho. Haeba moimana oa hau o e-so fele ka botlalo, ngaka ea hau e tla tšohla mekhoa e meng eo u ka e nahanang. U ka khetha ho ema, ho nka lethal dose le leng la misoprostol kapa ho etsoa opereishene ho felisa bokhachane. Haeba o nka tekanyetso e phetoang ea misoprostol, o tlameha ho ba le ketelo e latelang le ngaka ea hau matsatsing a 7 kamora tekanyetso eo ho netefatsa hore moimana o felile.

• bolella ngaka ea hau haeba u anyesa.

• haeba u ntse u etsoa opereishene, ho kenyeletsoa le ea meno, bolella ngaka kapa ngaka ea meno hore u nkile mifepristone.
• o lokela ho tseba hore kamora ho emisa ho ima le mifepristone, o ka ima hang hang, le pele nako ea hau ea ho khutla e khutla. Haeba u sa batle ho ima hape, u lokela ho qala ho sebelisa thibelo ea bokhachane hang ha bokhachane bona bo fela kapa pele u qala ho etsa thobalano hape.

Se ke oa nka mifepristone ka lero la litholoana tsa morara. Bua le ngaka ea hau ka ho noa lero la litholoana tsa morara kamora ho noa moriana ona.

U tla nka mifepristone feela ka ofising ea ngaka kapa tleliniking, ka hona ha ua lokela ho tšoenyeha ka ho lebala ho noa tefo lapeng.

Mifepristone e ka baka litla-morao. Bolella ngaka ea hau haeba a mang a matšoao ana a le matla kapa a sa fele:

• ho tsoa mali ka botšehaling kapa ponahalo ya mmele
• maqhubu
• bohloko ba pelvic
• ho chesa ka bosaling, ho hlohlona kapa ho tsoa hoa mali
• hlooho e opang

Litla-morao tse ling li ka ba mpe. Haeba u e-na le matšoao a boletsoeng karolong ea BOHLOKOA EA TEMOSO, letsetsa ngaka hang-hang.

Mifepristone e ka baka litla-morao tse ling. Bitsa ngaka ea hau haeba u na le mathata a sa tloaelehang ha u ntse u noa meriana ena.

Haeba o ba le litlamorao tse mpe, uena kapa ngaka ea hau le ka romella tlaleho ho Lenaneo la MedWatch Advers Event Reporting inthaneteng (http://www.fda.gov/Safety/MedWatch) inthaneteng kapa ka mohala ( 1-800-332-1088).

Ngaka ea hau e tla boloka meriana ka ofising ea eona.

Ho bohlokoa ho boloka litlhare tsohle li sa bonahale le moo bana ba ka fihlelloang lijana tse ngata (joalo ka likelello tsa lipilisi tsa beke le beke le tsa marotholi a mahlo, litlolo, lipache le li-inhalers) ha li thibele bana mme bana ba banyane ba ka li bula habonolo. Ho sireletsa bana ba banyenyane chefo, lula u notlela likepisi tsa polokeho 'me hang-hang beha meriana sebakeng se sireletsehileng - se holimo le hole le moo ba sa se boneng le ho se fihlela. http://www.upandaway.org

Haeba ho na le overdose, letsetsa mohala oa thuso oa taolo ea chefo ho 1-800-222-1222. Tlhahisoleseling e fumaneha inthaneteng ho https://www.poisonhelp.org/help. Haeba motho ea hlokofalitsoeng a oele, a tšoeroe ke sethoathoa, a na le bothata ba ho hema, kapa a sa khone ho tsosoa, hang-hang letsetsa litšebeletso tsa tšohanyetso ho 911.

Matšoao a ho feta tekano a ka kenyelletsa tse latelang:

• ho tsekela
• ho akheha
• pono e lerootho
• ho nyekeloa ke pelo
• mokgathala
• bofokoli
• phefumoloho e kgutshoane
• ho otla ha pelo kapele

U lokela ho fumana mifepristone feela ho ngaka e netefalitsoeng mme u sebelise meriana ena ha feela u le tlhokomelong ea ngaka. Ha ua lokela ho reka mifepristone mehloling e meng, joalo ka marang-rang, hobane u ne u tla tlola litšireletso tse bohlokoa ho sireletsa bophelo ba hau.

Se ke oa lumella mang kapa mang ho noa meriana ea hau.

Ho bohlokoa ho uena hore u boloke lethathamo le ngotsoeng la meriana eo u e nkang u sa e ngolla le eo u sa e ngolisetsang (morekisi) le lihlahisoa tse ling tse kang livithamini, liminerale, kapa litlatsetso tse ling tsa phepo. U lokela ho tla le lenane lena nako le nako ha u etela ngaka kapa ha u amoheloa sepetlele. Hape ke tlhaiso-leseling ea bohlokoa ho tsamaea le uena haeba ho ka hlaha maemo a tšohanyetso.

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