Sengoli: Clyde Lopez
Letsatsi La Creation: 24 Phupu 2021
Ntlafatsa Letsatsi: 11 Pherekhong 2025
Anonim
How does Niacin (B3) Work? (+ Pharmacology)
Video: How does Niacin (B3) Work? (+ Pharmacology)

Litaba

Niacin ke mofuta oa vithamine B3. E fumanoa lijong tse kang tomoso, nama, tlhapi, lebese, mahe, meroho e metala le lijo-thollo. Niacin e boetse e hlahisoa 'meleng ho tsoa ho tryptophan, e fumanoang lijong tse nang le protheine. Ha e nkoa e le tlatsetso, niacin hangata e fumanoa e kopane le livithamini tse ling tsa B.

Se ke oa ferekanya niacin le NADH, niacinamide, inositol nicotinate, IP-6, kapa tryptophan. Bona lenane le arohaneng la lihlooho tsena.

Mefuta ea lengolo la ngaka ea niacin e amoheloa ke Tsamaiso ea Lijo le Lithethefatsi ea Amerika (FDA) bakeng sa k'holeseterole e phahameng le ho eketsa maemo a mofuta o itseng oa k'holeseterole e ntle, e tsejoang e le HDL. Li-supplements tsa Niacin le lihlahisoa tsa ngaka le tsona li nkuoa ka molomo ho thibela khaello ea vithamine B3 le maemo a amanang le eona a kang pellagra.

Meriana ea Tlhahisoleseling e Akaretsang e sebetsa hantle ho ipapisitsoe le bopaki ba mahlale ho latela sekala se latelang: E ​​ea sebetsa, e ka sebetsa hantle, mohlomong ea sebetsa, mohlomong e sa sebetse, mohlomong e sa sebetse, e sa sebetse ebile e sa lekana Bopaki bo lokelang ho lekanyetsoa.

Likarolo tsa katleho ea NIACIN ke tse latelang:


E ka sebetsa hantle bakeng sa ...

  • Maemo a sa tloaelehang a k'holeseterole kapa mafura a mali (dyslipidemia). Lihlahisoa tse ling tsa niacin li amoheloa ke Tsamaiso ea Lijo le Lithethefatsi ea U.S. (FDA) e le lihlahisoa tsa lengolo la ngaka bakeng sa ho phekola mafura a mali a sa tloaelehang. Lihlahisoa tsena tsa ngaka tsa niacin hangata li ba le matla a phahameng a 500 mg kapa ho feta. Mefuta ea tlatsetso ea li-niacin hangata e tla ka matla a 250 mg kapa ka tlase. Kaha litekanyetso tse phahameng haholo tsa niacin lia hlokahala bakeng sa ho ntlafatsa maemo a k'holeseterole, tlatsetso ea phepo ea niacin hangata ha ea lokela. Niacin e ka kopanngoa le lithethefatsi tse ling tse theolelang k'holeseterole ha phepo le kalafo e le 'ngoe ea lithethefatsi e sa lekana. Niacin e ntlafatsa maemo a k'holeseterole, empa ha e ntlafatse sephetho sa pelo le methapo joalo ka lefu la pelo le stroke.
  • Lefu le bakoang ke khaello ea niacin (pellagra). Niacin e amoheloa ke Tsamaiso ea Lijo le Lithethefatsi ea U.S. (FDA) bakeng sa ts'ebeliso ena. Leha ho le joalo, niacin e ka baka "flushing" (bofubelu, ho hlohlona le ho hlohlona). Kahoo sehlahisoa se seng, se bitsoang niacinamide, ka linako tse ling se khethoa hobane ha se bake phello ena e lehlakoreng.

Mohlomong e sebetsa bakeng sa ...

  • Mefuta e sa tloaelehang ea mafura a mali ho batho ba nang le HIV / AIDS. Ho nka niacin ho bonahala ho ntlafatsa maemo a k'holeseterole le mafura a mali a bitsoang triglycerides ho bakuli ba nang le boemo bona.
  • Sehlopha sa matšoao a eketsang kotsi ea lefu la tsoekere, lefu la pelo le stroke (metabolic syndrome). Ho nka niacin ho bonahala ho eketsa maemo a high-density lipoprotein (HDL kapa "good") cholesterol le ho fokotsa maemo a mafura a mali a bitsoang triglycerides ho batho ba nang le ts'oaetso ea metabolic. Ho nka niacin hammoho le lengolo la ngaka la omega-3 fatty acid ho bonahala ho sebetsa le ho feta.

Ha e sebetse ...

  • Lefu la pelo. Patlisiso ea boleng bo holimo e bonts'a hore niacin ha e thibele tlhaselo ea pelo kapa stroke ho batho ba nkang niacin ho thibela kapa ho phekola lefu la pelo. Niacin le eona ha e so bontšoe ho fokotsa menyetla ea lefu. Niacin ha ea lokela ho nooa ho alafa kapa ho thibela lefu la pelo.

Bopaki bo sa lekaneng ba ho lekanya katleho ea ...

  • Ho thatafala ha methapo (atherosclerosis). Ho nka niacin ka molomo hammoho le meriana e bitsoang bile acid sequestrants ho ka fokotsa ho thatafala ha methapo ho banna ba nang le boemo bona. E bonahala e sebetsa hantle ho banna ba nang le mafura a mangata a mali a bitsoang triglycerides. Empa ho nka niacin ha ho bonahale ho fokotsa ho thatafala ha methapo ho bakuli ba nang le boemo bo bitsoang "peripheral arterial disease" (PAD). Hape, niacin ha e thibele liketsahalo tsa pelo le methapo joalo ka lefu la pelo kapa stroke.
  • Lefu la Alzheimer. Batho ba jang li-niacin tse ngata lijong le li-multivitamine ho bonahala ba na le monyetla o tlase oa ho fumana lefu la Alzheimer ho feta batho ba jang niacin e nyane. Empa ha ho na bopaki ba hore ho nka tlatsetso ea niacin ho thusa ho thibela lefu la Alzheimer.
  • Likotsi. Batho ba jang phepo e phahameng ea niacin ba ka ba le menyetla e fokotsehileng ea ho ba le lera la nyutlelie. Cataract ea nyutlelie ke mofuta oa cataract o atileng haholo. Phello ea ho nka niacin supplementation ha e tsejoe.
  • Tšoaetso ea mala a bakang letšollo (k'holera). Ho nka niacin ka molomo ho bonahala ho fokotsa letšollo ho batho ba nang le k'holera.
  • Ho se sebetse ha Erectile (ED). Ho nka niacin ea nako e telele pele ho robala bakeng sa libeke tsa 12 ho bonahala ho thusa banna ba nang le ED le maemo a phahameng a lipid ho boloka tsoekere nakong ea thobalano.
  • Maemo a phahameng a phosphate maling (hyperphosphatemia). Batho ba nang le ho hloleha ha liphio ba ka ba le phosphate e phahameng ea mali. Liphuputso tse ling tsa pejana li bonts'a hore ho nka niacin ho ka fokotsa phosphate ea mali ho batho ba nang le lefu la liphio qetellong le maemo a phahameng a phosphate ea mali. Empa lipatlisiso tse ling li bonts'a hore ho nka niacin ha ho theole phosphate ea mali ho batho ba ntseng ba noa meriana e sebelisetsoang ho theola maemo a phosphate ea mali.
  • Ho koaloa ha mothapo ka leihlong (ho koaloa ha methapo ea sefahleho): Patlisiso ea pejana e bonts'a hore ho nka niacin ho ka ntlafatsa pono ho batho ba nang le boemo bona.
  • Boloetse ba sele: Phuputso ea pejana e bonts'a hore ho nka niacin ha ho ntlafatse maemo a mafura a mali ho batho ba nang le lefu la sele ea sekele.
  • Makhopho.
  • Bothata ba tšebeliso ea joala.
  • Tshebetso ea liatleletiki.
  • Tlhokomelo ea tlhokomelo-lefu la ho se sebetse hantle (ADHD).
  • Ho tepella maikutlo.
  • Botsoa.
  • Likhopolo tse bakoang ke lithethefatsi.
  • Migraine.
  • Bokudi ba motsamao.
  • Boloetse ba kelello.
  • Maemo a mang.
Ho hlokahala bopaki bo bongata ho lekanya niacin bakeng sa ts'ebeliso ena.

Niacin e monngoa ke 'mele ha e qhibiliha ka metsing ebe e nkuoa ka molomo. E fetoleloa ho niacinamide haeba e nkuoa ka bongata bo fetang ba se hlokoang ke 'mele.

Niacin ea hlokahala bakeng sa tšebetso e nepahetseng ea mafura le tsoekere 'meleng le ho boloka lisele tse phetseng hantle. Ka tekanyetso e phahameng, niacin e ka thusa batho ba nang le lefu la pelo ka lebaka la litlamorao tse ntle tsa ho koala. E kanna ea ntlafatsa maemo a mofuta o itseng oa mafura a bitsoang triglycerides maling.

Ho haella ha Niacin ho ka baka boemo bo bitsoang pellagra, bo bakang ho teneha ha letlalo, letshollo le 'dementia'. Pellagra e ne e tloaelehile lekholong la mashome a mabeli la lilemo la lilemo, empa ha e sa tloaeleha hona joale, kaha lijo tse ling tse nang le phofo li se li matlafalitsoe ka niacin. Pellagra e se e felisitsoe moetlong oa bophirima.

Batho ba nang le phepo e nepahetseng, joala, le mefuta e meng ea lihlahala tse holang butle tse bitsoang lihlahala tsa carcinoid ba kanna ba ba kotsing ea ho haelloa ke niacin. Ha e nkoa ka molomo: Niacin ke TŠOANANG POLOKO bakeng sa batho ba bangata ha li nkuoa ka nepo. Lihlahisoa tsa ngaka tse nang le niacin li bolokehile ha li nkuoa joalo ka ha li laetsoe. Lijo tse nang le Niacin kapa li-supplement tsa niacin li bolokehile ha li nooa ka tekanyetso e ka tlase ho 35 mcg ka letsatsi.

Sephetho se tloaelehileng sa niacin ke karabelo e phallang. Sena se ka baka ho chesa, ho hlohlona, ​​ho hlohlona le ho ba khubelu sefahlehong, matsohong le sefubeng, hammoho le ho opeloa ke hlooho. Ho qala ka litekanyo tse nyane tsa niacin le ho noa 325 mg ea aspirin pele lethalko le leng le le leng la niacin le tla thusa ho fokotsa ho phatloha ho hoholo. Hangata, karabelo ena ea fela ha 'mele o tloaela meriana. Joala bo ka mpefatsa tšabo ea motho eo a mo fafatsang. Qoba joala bo bongata ha o ntse o nka niacin.

Litla-morao tse ling tse nyane tsa niacin ke ho ferekana ka mpeng, khase ea mala, ho tsekela, bohloko ba molomo le mathata a mang.

Ha ho nkoa litekanyo tsa ligrama tse fetang 3 ka letsatsi la niacin, litla-morao tse tebileng li ka etsahala. Tsena li kenyelletsa mathata a sebete, gout, liso tsa tšilo ea lijo, ho se bone hantle, tsoekere e phahameng maling, ho otla ha pelo ka tsela e sa tloaelehang le mathata a mang a tebileng.

Litlhokomelo le litemoso tse khethehileng:

Bokhachane le ho anyesa: Niacin ke TŠOANANG POLOKO bakeng sa bakhachane le ba anyesang ha ba nooa ka molomo ka chelete e khothalletsoang. Palo e phahameng e khothalletsoang ea niacin bakeng sa basali ba baimana kapa ba anyesang ke 30 mg ka letsatsi bakeng sa basali ba ka tlase ho lilemo tse 18, le 35 mg bakeng sa basali ba fetang lilemo tse 18.

Bana: Niacin ke TŠOANANG POLOKO ha e nkoa ka molomo ka chelete e khothalletsoang bakeng sa sehlopha ka seng sa lilemo. Empa bana ba lokela ho qoba ho noa niacin kaholimo ho meeli e kaholimo ea letsatsi, e leng 10 mg bakeng sa bana ba lilemo li 1-3, 15 mg bakeng sa bana ba lilemo li 4-8, 20 mg bakeng sa bana ba lilemo li 9-13, le 30 mg bakeng sa bana ba lilemo li 14-18.

Maloetse: Niacin e ka mpefatsa ho kula ho hoholo ka ho baka hore histamine, khemikhale e ikarabellang bakeng sa matšoao a kulisang, e lokolloe.

Lefu la pelo / angina e sa tsitsang: Nete e ngata e ka eketsa kotsi ea ho otla ha pelo ka tsela e sa tloaelehang. Sebelisa ka hloko.

Lefu la Crohn: Batho ba nang le lefu la Crohn ba kanna ba ba le maemo a tlase a niacin mme ba hloka tlatsetso nakong ea bohale.

Lefu la tsoekere: Niacin e ka eketsa tsoekere maling. Batho ba nang le lefu la tsoekere ba noang niacin ba lokela ho hlahloba tsoekere ea mali ka hloko.

Lefu la gallbladder: Niacin e ka mpefatsa lefu la gallbladder.

Gout: Niacin e ngata e ka tlisa gout.

Lefu la liphio: Niacin e ka bokellana ho batho ba nang le lefu la liphio. Sena se ka baka kotsi.

Lefu la sebete: Niacin e ka eketsa tšenyo ea sebete. U se ke ua sebelisa bongata haeba u e-na le lefu la sebete.

Diso tsa ka maleng kapa mala: Niacin e ka mpefatsa liso. U se ke ua sebelisa bongata haeba u na le liso.

Khatello ea mali e tlase haholo: Niacin e ka fokotsa khatello ea mali mme ea mpefatsa boemo bona.

Phekolo: Niacin e ka kena-kenana le taolo ea tsoekere maling nakong le kamora 'opereishene. Khaotsa ho noa niacin bonyane libeke tse 2 pele ho opereishene e reriloeng.

Mafura a beha haufi le tendon (tendon xanthomas): Niacin e ka eketsa kotsi ea tšoaetso ho xanthomas.

Mathata a qoqotho: Thyroxine ke hormone e hlahisoang ke tšoelesa ea qoqotho. Niacin e ka theola mali a thyroxine. Sena se ka mpefatsa matšoao a mafu a itseng a qoqotho.

E itekanetse
E-ba hlokolosi ka motsoako ona.
Joala (Ethanol)
Niacin e ka baka ho hohola le ho hlohlona. Ho noa joala hammoho le niacin ho ka etsa hore ho hohola le ho hlohlona ho mpefale le ho feta. Hape ho na le matšoenyeho a hore ho noa joala le niacin ho ka eketsa menyetla ea ho senyeha ha sebete.
Allopurinol (Zyloprim)
Allopurinol (Zyloprim) e sebelisetsoa ho alafa gout. Ho noa tekanyetso e kholo ea niacin ho ka mpefatsa gout le ho fokotsa ts'ebetso ea allopurinol (Zyloprim).
Clonidine (Catapres)
Clonidine le niacin khatello e tlase ea mali ka bobeli. Ho nka niacin le clonidine ho ka etsa hore khatello ea mali ea hau e theohe haholo.
Gemfibrozil (Lopid)
Ho nka niacin hammoho le gemfibrozil ho ka baka tšenyo ea mesifa ho batho ba bang. Sebelisa ka hloko.
Meriana ea lefu la tsoekere (Lithethefatsi tsa Antidiabetes)
Tšebeliso ea litekanyetso tse phahameng tsa niacin (e ka bang ligrama tse 3-4 ka letsatsi) e ka eketsa tsoekere maling. Ka ho eketsa tsoekere ea mali, niacin e ka fokotsa katleho ea meriana ea lefu la tsoekere. Hlahloba tsoekere ea hao ea mali haufi-ufi. Tekanyo ea meriana ea lefu la tsoekere e kanna ea hloka ho fetoloa.

Meriana e meng e sebelisetsoang lefu la tsoekere e kenyelletsa glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), chlorpropamide Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), le tse ling.
Meriana ea khatello e phahameng ea mali (Lithethefatsi tse matlafatsang)
Ho sebelisa niacin le lithethefatsi tse fokotsang khatello ea mali ho ka eketsa litlamorao tsa lithethefatsi tsena mme ho ka fokotsa khatello ea mali haholo.

Meriana e meng ea khatello e phahameng ea mali e kenyelletsa captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), le tse ling tse ngata. .
Meriana e ka lematsang sebete (lithethefatsi tsa Hepatotoxic)
Niacin e ka senya sebete. Litokisetso tsa niacin tse lokolloang ka thata li bonahala li na le kotsi e kholo. Ho nka niacin hammoho le meriana e ka lematsang sebete ho ka eketsa menyetla ea ho senyeha ha sebete. Se ke oa noa niacin haeba o noa moriana o ka lematsang sebete.

Meriana e meng e ka lematsang sebete e kenyelletsa acetaminophen (Tylenol le tse ling), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporaconazole) erythromycin (Erythrocin, Ilosone, tse ling), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), le tse ling tse ngata.
Meriana e liehang ho koala mali (Anticoagulant / Antiplatelet drug)
Niacin e ka liehisa ho hoama ha mali. Ho noa niacin hammoho le meriana e fokotsang ho hoama e ka 'na ea eketsa menyetla ea ho longoa le ho tsoa mali.

Meriana e meng e liehang ho koala mali e kenyelletsa aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), le tse ling.
Meriana e sebelisetsoang ho theola k'holeseterole (Bile acid sequestrants)
Meriana e meng ea ho theola k'holeseterole e bitsoang bile acid sequestrants e ka fokotsa hore naine e monya 'mele o kae. Sena se ka fokotsa katleho ea niacin. Nka niacin le meriana bonyane li arohane ka lihora tse 4-6.

E meng ea meriana ena e sebelisetsoang ho theola k'holeseterole e kenyelletsa cholestyramine (Questran) le colestipol (Colestid).
Meriana e sebelisetsoang ho theola k'holeseterole (Statins)
Niacin e ka ama mesifa hampe. Meriana e meng e sebelisetsoang ho theola k'holeseterole e bitsoang li-statins le eona e ka ama mesifa. Ho noa niacin hammoho le meriana ena ho ka eketsa kotsi ea mathata a mesifa.

E meng ea meriana ena e sebelisetsoang k'holeseterole e phahameng e kenyelletsa rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol) le simvastatin (Zocor).
Probenecid (Benemid)
Probenecid e sebelisetsoa ho alafa gout. Ho nka tekanyetso e kholo ea niacin ho ka mpefatsa gout le ho fokotsa ts'ebetso ea probenecid.
Sulfinpyrazone (Anturane)
Sulfinpyrazone (Anturane) e sebelisetsoa ho alafa gout. Ho nka tekanyetso e kholo ea niacin ho ka mpefatsa gout le ho fokotsa ts'ebetso ea sulfinpyrazone (Anturane).
Hormone ea qoqotho
'Mele ka tlhaho o hlahisa lihomone tsa qoqotho. Niacin e ka fokotsa maemo a lihormone tsa qoqotho. Ho noa niacin ka lipilisi tsa qoqotho ho ka fokotsa litla-morao le litla-morao tsa hormone ea qoqotho.
Nyane
Ela hloko ka motswako ona.
Aspirine
Aspirin hangata e sebelisoa le niacin ho fokotsa ho hohola ho bakoang ke niacin. Ho noa aspirin e ngata ho ka fokotsa hore na 'mele o tlosa niacin kapele hakae. Sena se ka baka hore ho be le niacin e ngata haholo 'meleng mme mohlomong e lebise litlamorao. Leha ho le joalo, tekanyetso e tlase ea aspirin e sebelisoang haholo bakeng sa ho hohola e amanang le niacin ha e bonahale e le bothata.
Nicotine patch (Nicoderm)
Niacin ka linako tse ling e ka baka ho hohola le ho tsekela. Patch ea nicotine e ka baka ho hohola le ho tsekela. Ho nka niacin kapa niacinamide le ho sebelisa setsi sa nicotine ho ka eketsa monyetla oa ho ba le metsi le ho tsekela.
Beta-carotene
Motsoako oa niacin le moriana oa ngaka simvastatin (Zocor) o phahamisa HDL (high density lipoprotein) cholesterol ("cholesterol e ntle") ho batho ba nang le lefu la pelo le maemo a tlase a HDL. Leha ho le joalo, ho nka niacin hammoho le metsoako ea li-antioxidants, ho kenyeletsoa le beta-carotene, ho bonahala e le phoso ho nyoloha hona ha HDL. Ha ho tsejoe hore na phello ena e etsahala ho batho ba se nang lefu la pelo.
Chromium
Ho nka niacin le chromium hammoho ho ka fokotsa tsoekere maling. Haeba u na le lefu la tsoekere 'me u noa li-chromium le niacin hammoho, lekola tsoekere ea mali ho etsa bonnete ba hore ha e theohe haholo.
Litlama le litlatsetso tse ka lematsang sebete
Niacin, haholo-holo ka tekanyetso e phahameng e ka baka tšenyo ea sebete. Ho nka niacin hammoho le litlama tse ling kapa litlatsetso tse ka lematsang sebete ho ka eketsa kotsi ena. Tse ling tsa lihlahisoa tsena li kenyelletsa androstenedione, lekhasi la borage, chaparral, comfrey, dehydroepiandrosterone (DHEA), germander, kava, oli ea pennyroyal, tomoso e khubelu le tse ling.
Litlama le litlatsetso tse ka fokotsang khatello ea mali
Niacin e ka fokotsa khatello ea mali. Ho noa niacin ka litlama tse ling le litlatsetso tse fokotsang khatello ea mali ho ka baka khatello ea mali ho theoha haholo. Litlama tse ling le li-supplements tse ka fokotsang khatello ea mali li kenyelletsa andrographis, casein peptides, claw's cat, coenzyme Q10, L-arginine, lycium, neting nettle, theanine, le tse ling.
Litlama le litlatsetso tse ka liehang ho koala mali
Niacin e ka liehisa ho hoama ha mali. Ho sebelisa niacin hammoho le litlama tse ling le litlatsetso tse fokotsang ho hoama ha mali ho ka eketsa menyetla ea ho tsoa mali bathong ba bang. Litlama tse ling tsa mofuta ona li kenyelletsa angelica, clove, danshen, konofolo, ginger, Panax ginseng le tse ling.
Tee ea Kombucha
Ho na le matšoenyeho a mang a hore tee ea kombucha e ka fokotsa ho kenella ha niacin. Leha ho le joalo, sena se hloka ho ithutoa haholoanyane.
Selenium
Motsoako oa niacin le moriana oa ngaka simvastatin (Zocor) o phahamisa HDL (high density lipoprotein) cholesterol ("cholesterol e ntle") ho batho ba nang le lefu la pelo le maemo a tlase a HDL. Leha ho le joalo, ho nka niacin hammoho le metsoako ea li-antioxidants, ho kenyeletsoa le selenium, ho bonahala e le phoso ho nyoloha ha HDL. Ha ho tsejoe hore na phello ena e etsahala ho batho ba se nang lefu la pelo.
Lehlohonolo
Mefuta e meng ea tryptophan e tsoang lijong e ka fetoloa niacin 'meleng. Ho nka niacin le tryptophan hammoho ho ka eketsa maemo le litla-morao tsa niacin.
Vithamine C
Motsoako oa niacin le moriana oa ngaka simvastatin (Zocor) o phahamisa HDL (high density lipoprotein) cholesterol ("cholesterol e ntle") ho batho ba nang le lefu la pelo le maemo a tlase a HDL. Leha ho le joalo, ho nka niacin hammoho le metsoako ea li-antioxidants, ho kenyeletsoa le vithamine C, ho bonahala e le phoso ho nyoloha ha HDL. Ha ho tsejoe hore na phello ena e etsahala ho batho ba se nang lefu la pelo.
Vithamine E
Motsoako oa niacin le moriana oa ngaka simvastatin (Zocor) o phahamisa HDL (high density lipoprotein) cholesterol ("cholesterol e ntle") ho batho ba nang le lefu la pelo le maemo a tlase a HDL. Leha ho le joalo, ho nka niacin hammoho le metsoako ea li-antioxidants, ho kenyeletsoa vithamine E, ho bonahala e le phoso ho nyoloha ha HDL. Ha ho tsejoe hore na phello ena e etsahala ho batho ba se nang lefu la pelo.
Zinki
'Mele o ka etsa niacin. Batho ba sa fepehang hantle 'me ba na le khaello ea niacin, joalo ka joala bo sa foleng, ba etsa niacin e eketsehileng haeba ba noa zinc. Ho ka 'na ha e-ba le kotsi e eketsehileng ea litla-morao tse amanang le niacin tse kang ho tsuba le ho hlohlona haeba niacin le zinki li nkoa hammoho.
Lino tse chesang
Niacin e ka baka ho hohola le ho hlohlona. Litholoana tsena li ka eketsoa haeba niacin e nkoa ka seno se chesang.
Litekanyo tse latelang li ithutiloe lipatlisisong tsa mahlale:

BAHOLO

KA MOLOMO:
  • Kakaretso: Lihlahisoa tse ling tsa tlatsetso ea lijo li thathamisa niacin lethathamong la li-niacin equivalents (NE). 1 mg ea niacin e ts'oana le 1 mg NE. Ha niacin e thathamisitsoe lethathamong la NE, e kanna ea kenyelletsa mefuta e meng ea niacin hape, ho kenyeletsoa niacinamide, inositol nicotinate le tryptophan. Meputso ea letsatsi le letsatsi e khothalletsoang lijo (RDAs) bakeng sa niacin ho batho ba baholo ke 16 mg NE bakeng sa banna, 14 mg NE bakeng sa basali, 18 mg NE bakeng sa bakhachane, le 17 mg NE bakeng sa basali ba anyesang.
  • Bakeng sa k'holeseterole e phahameng: Litlamorao tsa niacin li its'etleha ka tekanyetso. Litekanyo tsa niacin tse ka tlaase ho 50 mg le tse phahameng ho fihlela ho ligrama tse 12 ka letsatsi li sebelisitsoe. Leha ho le joalo, keketseho e kholo ho HDL mme e fokotseha ho triglycerides e etsahala ka 1200 ho isa ho 1500 mg / ka letsatsi. Litholoana tse kholo tsa Niacin ho LDL li etsahala ka 2000 ho isa ho 3000 mg / ka letsatsi. Niacin hangata e sebelisoa le meriana e meng bakeng sa ho ntlafatsa maemo a k'holeseterole.
  • Bakeng sa ho thibela le ho phekola khaello ea vithamine B3 le maemo a amanang le eona joalo ka pellagra: 300-1000 mg ka letsatsi ka litekanyetso tse arohaneng.
  • Bakeng sa ho phekola ho thatafala ha methapo: Tekanyo ea niacin e phahame ka ligrama tse 12 ka letsatsi. Leha ho le joalo, tekanyetso ea ligrama tse 1 ho isa ho tse 4 tsa niacin letsatsi le letsatsi, e le mong kapa hammoho le li-statins kapa bile acid sequestrants (moriana o theolelang k'holeseterole), e sebelisitsoe ho fihlela lilemo tse 6.2.
  • Bakeng sa ho fokotsa tahlehelo ea mokelikeli e bakoang ke chefo ea k'holera: Ho sebelisitsoe ligrama tse 2 ka letsatsi.
  • Bakeng sa maemo a sa tloaelehang a mafura a mali ka lebaka la kalafo ea HIV / AIDSHo sebelisoa ligrama tse 2 ka letsatsi.
  • Bakeng sa metabolic syndrome: 2 dikgerama tsa niacin li nkiloe letsatsi le letsatsi bakeng sa libeke tse 16. Maemong a mang, niacin 2 dikgerama ka letsatsi, a le mong kapa tekanyong ena, e nkoa hammoho le ligrama tse 4 tsa omega-3 ethyl esters (Lovaza, GlaxoSmithKline Pharmaceuticals).
KA IV:
  • Bakeng sa ho thibela le ho phekola khaello ea vithamine B3 le maemo a amanang le eona joalo ka pellagra: Ho sebelisitsoe 60 mg ea niacin.
JOALOKAHA Thunya:
  • Bakeng sa ho thibela le ho phekola khaello ea vithamine B3 le maemo a amanang le eona joalo ka pellagra: Ho sebelisitsoe 60 mg ea niacin.
BANA

KA MOLOMO:
  • Kakaretso: Meputso ea lijo ea letsatsi le letsatsi e khothalletsoang (RDAs) bakeng sa niacin ho bana ke 2 mg NE bakeng sa masea a likhoeli tse 0-6, 4 mg NE bakeng sa masea a likhoeli tse 7-12, 6 mg NE bakeng sa bana ba lilemo li 1-3, 8 mg NE bakeng sa bana ba lilemo li 4-8, 12 mg NE bakeng sa bana ba lilemo li 9-13, 16 mg NE bakeng sa bashanyana ba lilemo li 14-18, le 14 mg NE bakeng sa banana ba lilemo li 14-18.
  • Bakeng sa ho thibela le ho phekola khaello ea vithamine B3 le maemo a amanang le eona joalo ka pellagra: 100-300 mg ka letsatsi la niacin, e fanoang ka litekanyo tse arohaneng.
3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complexe de Vitamines B, Facteur Anti-Pellagre, Niacina, Niacine, Nicosedine, Nicotinic Aciding, Pelo ea Nicotinra Vithamine B3, Vithamine PP, Vitamina B3, Vitamine B3, Vitamine PP.

Ho ithuta haholoanyane ka hore na sengoloa sena se ngotsoe joang, ka kopo bona Meriana ea Tlhahisoleseling e Akaretsang mokhoa.


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