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Apolipoproteins | USMLE Step 1 Biochem Mnemonics
Video: Apolipoproteins | USMLE Step 1 Biochem Mnemonics

Apolipoprotein CII (apoCII) ke protheine e fumanoang likarolong tse kholo tsa mafura tse monyang masapo. E boetse e fumanoa ka lipoprotein (VLDL) tse tlase haholo, tse entsoeng ka boholo ba triglycerides (mofuta oa mafura maling a hau).

Sengoloa sena se bua ka tlhahlobo e sebelisitsoeng ho hlahloba apoCII sampoleng ea mali a hau.

Ho hlokahala sampole ea mali.

U ka bolelloa hore u se ke ua ja kapa ua noa letho lihora tse 4 ho isa ho tse 6 pele ho tlhahlobo.

Ha nale e kentsoe ho hula mali, o kanna oa utloa bohloko bo itseng, kapa ho hlaba kapa ho hlaba feela. Kamora moo, ho kanna ha ba le ho tsitsipana moo nale e kentsoeng.

Litekanyo tsa ApoCII li ka thusa ho tseba mofuta kapa sesosa sa mafura a phahameng a mali. Ha ho hlake hore na liphetho tsa liteko li ntlafatsa kalafo. Ka lebaka la sena, lik'hamphani tse ngata tsa inshorense ea bophelo bo botle li ke ke tsa lefella tlhahlobo. Haeba O SE na k'holeseterole e phahameng kapa lefu la pelo kapa nalane ea lelapa ea maemo ana, tlhahlobo ena e kanna ea se khothalletsoe uena.


Mefuta e tloaelehileng ke 3 ho isa ho 5 mg / dL. Leha ho le joalo, liphetho tsa apoCII hangata li tlalehoa li le teng kapa li le sieo.

Mehlala e kaholimo ke litekanyo tse tloaelehileng bakeng sa liphetho tsa liteko tsena. Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li leka liteko tse fapaneng. Bua le ngaka ea hau ka se boleloang ke sephetho sa hau sa liteko.

Maemo a phahameng a apoCII a ka bakoa ke nalane ea lelapa ea ho haella ha lipoprotein lipase. Ena ke boemo boo 'mele o sa senyeheng mafura ka mokhoa o tloaelehileng.

Maemo a ApoCII a boetse a bonoa ho batho ba nang le boemo bo sa tloaelehang bo bitsoang "apoprotein" ea malapa e haelloang ke CII. Sena se baka lefu la chylomicronemia, boemo bo bong moo 'mele o sa senyeheng mafura ka mokhoa o tloaelehileng.

Likotsi tse amanang le ho huloa mali li nyane empa li ka kenyelletsa:

  • Ho tsoa mali a mangata
  • Ho akheha kapa ho ikutloa o le hlooho e boima
  • Hematoma (mali a bokellanang ka tlasa letlalo)
  • Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Litekanyo tsa Apolipoprotein li ka fana ka lintlha tse qaqileng mabapi le kotsi ea lefu la pelo, empa boleng bo ekelitsoeng ba tlhahlobo ena ho feta karolo ea lipid ha bo tsejoe.


ApoCII; Apoprotein CII; ApoC2; Ho haella ha lipoprotein lipase - apolipoprotein CII; Chylomicronemia syndrome - apolipoprotein CII

  • Teko ea mali

Chen X, Zhou L, Hussain MM. Lipids le dyslipoproteinemia. Ka: McPherson RA, Pincus MR, bahlophisi. Henry's Clinical Diagnosis le Tsamaiso ka Mekhoa ea Laboraro. La bo23 la ed. St Louis, MO: Elsevier; 2017: khaolo ea 17.

Genest J, Libby P. Lipoprotein mathata le lefu la pelo. Ka: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Lefu la pelo la Braunwald: Buka ea bongaka ea meriana ea pelo. 11th ed. Philadelphia, PA: Elsevier; 2019: khaolo ea 48.

Remaley AT, Mantsiboea TD, Warnick GR. Lipids, lipoprotein, apolipoprotein, le lisosa tse ling tsa kotsi ea pelo. Ka: Rifai N, ed. Tietz ea Buka ea Khemistri ea Kliniki le Diagnostics ea Limolek'hule. La 6th. St Louis, MO: Elsevier; 2018: khaolo ea 34.


Robinson JG. Mathata a metabolism ea lipid. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 195.

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