Teko ea mali ea TBG

Teko ea mali ea TBG e lekanya boemo ba protheine e tsamaisang lihormone tsa qoqotho 'meleng oa hau. Protheine ena e bitsoa thyroxine binding globulin (TBG).

Sampole ea mali e nkuoa ebe e romelloa laboratoring ho ea hlahlojoa.

Lithethefatsi le meriana e meng e ka ama sephetho sa liteko. Mofani oa hao oa tlhokomelo ea bophelo a ka u joetsa hore u khaotse ho noa moriana o itseng nakoana pele ho tlhahlobo. Le ka mohla u se ke ua emisa ho noa moriana u sa bua le mofani oa litšebeletso pele.

Meriana le lithethefatsi tsena li ka eketsa boemo ba TBG:

• Estrogens, e fumanoang lipilisi tsa thibelo ea bokhachane le kalafo ea phetolo ea estrogen
• Heroin
• Methadone
• Phenothiazines (lithethefatsi tse ling tse thibelang mafu)

Meriana e latelang e ka fokotsa maemo a TBG:

• Depakote kapa depakene (eo hape e bitsoang valproic acid)
• Dilantin (eo hape e bitsoang phenytoin)
• Tekanyo e phahameng ea li-salicylate, ho kenyelletsa le aspirin
• Lihormone tsa banna, ho kenyeletsoa androgens le testosterone
• Prednisone

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba ikutloa feela ho hlaba kapa ho hlaba. Kamora moo, ho kanna ha ba le ho longoa kapa ho longoa hanyenyane. Haufinyane sena sea fela.

Teko ena e ka etsoa ho fumana mathata ka qoqotho ea hau.

Mefuta e tloaelehileng ke li-micrograms tse 13 ho isa ho tse 39 ka desilitara (mcg / dL), kapa li-nanomoles tse 150 ho isa ho tse 360 ​​ka litha e le nngwe (nmol / L).

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Labs tse ling li sebelisa litekanyo tse fapaneng kapa li kanna tsa leka mehlala e fapaneng. Bua le mofani oa hau ka moelelo oa sephetho sa hau sa liteko.

Lebelo le eketsehang la TBG le ka bakoa ke:

• Acute intermittent porphyria (lefu le sa tloaelehang la metabolism)
• Hypothyroidism (qoqotho e sa sebetseng)
• Lefu la sebete
• Bokhachane (maemong a TBG hangata a eketseha nakong ea bokhachane)

Tlhokomeliso: Hangata litekanyetso tsa TBG li phahame ho masea a sa tsoa tsoaloa.

Ho fokotseha ha maemo a TBG ho ka bakoa ke:

• Boloetse bo bohloko
• Acromegaly (bothata bo bakoang ke kholo ea kholo ea hormone)
• Hyperthyroidism (thyroid e feteletseng)
• Khaello ea phepo e nepahetseng
• Nephrotic syndrome (matšoao a bontšang tšenyo ea liphio a teng)
• Khatello ea maikutlo ho tloha ho buuoa

Maemo a phahameng kapa a tlase a TBG a ama kamano lipakeng tsa kakaretso ea T4 le liteko tsa mahala tsa T4 tsa mali. Phetoho ea maemo a mali a TBG e ka fetola lethal dose levothyroxine bakeng sa batho ba nang le hypothyroidism.

Ha ho na kotsi e kholo ea ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho fumana sampole ea mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tsa ho huloa mali li nyane, empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Li-punctures tse ngata ho fumana methapo
• Hematoma (mali a hahiloeng ka tlas'a letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Serum thyroxine e tlamang globulin; Tekanyo ea TBG; Boemo ba Serum TBG; Hypothyroidism - TBG; Hyperthyroidism - TBG; Qoqotho e sa sebetseng - TBG; Thyroid e feteletseng - TBG

• Teko ea mali

Guber HA, Farag AF. Tlhatlhobo ea ts'ebetso ea endocrine. Ka: McPherson RA, Pincus MR, bahlophisi. Henry's Clinical Diagnosis le Tsamaiso ka Mekhoa ea Laboraro. La bo23 la ed. St Louis, MO: Elsevier; 2017: khaolo ea 24.

Kruse JA. Mathata a qoqotho. Ka: Parrillo JE, Dellinger RP, bahlophisi. Meriana e Hlokahalang ea Tlhokomelo: Melao-motheo ea Tlhahlobo le Tsamaiso ho Motho e Moholo. La 5th. Philadelphia, PA: Elsevier; 2019: khaolo ea 57.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Thyroid pathophysiology le tlhahlobo ea tlhahlobo. Ka: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, bahlophisi. Buka ea Williams ea Endocrinology. La bo14 la ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 11.