Nevoid basal cell carcinoma lefu

Nevoid basal cell carcinoma syndrome ke sehlopha sa liphoso tse fetang malapeng. Boloetse bona bo kenyelletsa letlalo, tsamaiso ea methapo, mahlo, litšoelesa tsa endocrine, lits'ebetso tsa ho ntša metsi le ho hlahisa le masapo.

E baka ponahalo e sa tloaelehang ea sefahleho le kotsi e kholo ea mofetše oa letlalo le lihlahala tse se nang mofetše.

Nevoid basal cell carcinoma nevus syndrome ke boemo bo sa tloaelehang ba liphatsa tsa lefutso. Jini e ka sehloohong e hokahantsoeng le lefu lena e tsejoa e le PTCH ("e patched"). Jini ea bobeli, e bitsoang SUFU, le eona e amahanngoa le boemo bona.

Lintho tse sa tloaelehang liphatseng tsena tsa lefutso hangata li fetisoa ke malapa e le tšobotsi e ka sehloohong ea li-autosomal. Sena se bolela hore o ba le lefu lena haeba motsoali e mong au fetisetsa liphatsa tsa lefutso. Hape hoa khonahala ho hlahisa sekoli sena sa lefutso se se nang nalane ea lelapa.

Matšoao a mantlha a lefu lena ke:

• Mofuta oa mofetše oa letlalo o bitsoang basal cell carcinoma o hlahang nakong ea bocha
• Lehlahala le sa hlajoeng ke mohlahare le bitsoang kerotocystic odontogenic hlahala le lona le hlahang nakong ea bocha.

Matšoao a mang a kenyelletsa:

• Nko e sephara
• Molomo o petsohileng
• Phatla e boima, e hlahelletseng
• Mohlahare o tsoang ka ntle (maemong a mang)
• Mahlo a bulehileng ka bophara
• Ho palama matsoho le bohato

Boemo bo ka ama tsamaiso ea methapo mme ea lebisa ho:

• Mathata a mahlo
• Ho se utloe litsebeng
• Bokooa ba kelello
• Ho oa
• Lihlahala tsa boko

Boemo bona bo boetse bo lebisa ho bofokoli ba masapo, ho kenyelletsa:

• Ho kobeha ha mokokotlo (scoliosis)
• Ho kobeha ho matla ha mokokotlo (kyphosis)
• Likhopo tse sa tloaelehang

Ho kanna ha ba le nalane ea lelapa ea lefu lena le nalane e fetileng ea mofetše oa basal cell.

Liteko li ka senola:

• Lihlahala tsa boko
• Li-cysts mohlahareng, tse ka lebisang nts'etsopele e sa tloaelehang ea meno kapa ho robeha ha mohlahare
• Liphoso karolong e mebala (iris) kapa lense ea leihlo
• Ho ruruha hloohong ka lebaka la mokelikeli bokong (hydrocephalus)
• Lintho tse sa tloaelehang tsa likhopo

Liteko tse ka etsoang li kenyelletsa:

• Echocardiogram ea pelo
• Ho lekoa ka liphatsa tsa lefutso (ho bakuli ba bang)
• MRI ea boko
• Letlalo la biopsy la lihlahala
• X-ray ea masapo, meno le lehata
• Ultrasound ho hlahloba lihlahala tsa mae a bomme

Ho bohlokoa ho hlahlojoa ke ngaka ea letlalo (dermatologist) khafetsa, e le hore mofetše oa letlalo o ka phekoloa o sa le monyane.

Batho ba nang le bothata bona le bona ba ka bonoa mme ba phekoloa ke litsebi tse ling, ho latela hore na ke karolo efe ea 'mele e amehileng. Mohlala, setsebi sa mofets'e (oncologist) se ka alafa lihlahala 'meleng, mme ngaka e buoang ea masapo e ka thusa ho alafa mathata a masapo.

Ho latela khafetsa lingaka tse fapaneng tsa litsebi ho bohlokoa bakeng sa ho ba le sephetho se setle.

Batho ba nang le boemo bona ba ka nts'etsapele:

• Bofofu
• Hlahala ea boko
• Ho se utloe litsebeng
• Ho robeha hoa dikarolo
• Lihlahala tsa mae a bomme
• Li-fibromas tsa pelo
• Ho senyeha ha letlalo le mabali a maholo ka lebaka la mofetše oa letlalo

Ikopanye le mofani oa tlhokomelo ea bophelo bakeng sa kopano haeba:

• Uena kapa litho life kapa life tsa lelapa le na le lefu la basal cell carcinoma, haholo-holo haeba u rera ho ba le ngoana.
• U na le ngoana ea nang le matšoao a lefu lena.

Banyalani ba nang le nalane ea lelapa ea lefu lena ba ka nahana ka tlhabollo ea lefutso pele ba ima.

Ho lula kantle letsatsing le ho sebelisa setlolo se sireletsang letlalo letsatsing ho ka thusa ho thibela mofetše o mocha oa letlalo la basal cell.

Qoba mahlaseli a kang x-ray. Batho ba nang le boemo bona ba hlokolosi haholo mahlaseling. Ho pepesehela mahlaseli a kotsi ho ka lebisa ho mofetše oa letlalo.

Lefu la NBCC; Lefu la Gorlin; Lefu la Gorlin-Goltz; Basal cell nevus syndrome (BCNS); Kankere ea basal cell - nevoid basal cell carcinoma syndrome

• Basal cell nevus syndrome - ho koaloa ha palema
• Basal cell nevus syndrome - likoti tsa limela
• Basal cell nevus syndrome - sefahleho le letsoho
• Basal cell nevus lefu
• Basal cell nevus syndrome - sefahleho

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Skelsey MK, Peck GL. Nevoid basal cell carcinoma lefu. Ka: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, bahlophisi. Kalafo ea Mafu a Letlalo: Mekhoa e Phethahetseng ea Phekolo. La 5th. Philadelphia, PA: Elsevier; 2018: khaolo ea 170.

Walsh MF, Cadoo K, Salo-Mullen EE, Dubard-Gault M, Stadler ZK, Offit K. Lintho tsa lefutso: kankere ea lefutso e tlatsetsang syndromes. Ka: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, bahlophisi. Abeloff's Clinical Oncology. La 6th. Philadelphia, PA: Elsevier; 2020: khaolo ea 13.