Bokheleke

Gigantism ke kholo e sa tloaelehang ka lebaka la kholo e fetelletseng ea kholo ea hormone (GH) nakong ea bongoana.

Gigantism ha e fumanehe hangata. Lebaka le tloaelehileng haholo la ho lokolloa ha GH haholo ke hlahala e sa kankere (benign) ea tšoelesa ea pituitary. Lisosa tse ling li kenyelletsa:

• Lefu la lefutso le amang 'mala oa letlalo (pigmentation) mme le baka sethopo se kotsi sa letlalo, pelo le endocrine (hormone) (Carney complex)
• Lefu la lefutso le amang masapo le 'mala oa letlalo (McCune-Albright syndrome)
• Lefu la liphatsa tsa lefutso moo e le 'ngoe kapa tse ling tsa litšoelesa tsa endocrine li sebetsang haholo kapa li etsa hlahala (multiple endocrine neoplasia mofuta oa 1 kapa mofuta oa 4)
• Boloetse ba lefutso bo etsang lihlahala tsa pituitary
• Lefu leo ​​ho lona lihlahala li bang teng methapong ea boko le mokokotlong (neurofibromatosis)

Haeba GH e fetelletseng e hlaha kamora hore kholo e tloaelehileng ea masapo e emise (pheletso ea bocha), boemo boo bo tsejoa e le acromegaly.

Ngoana o tla hola ka bolelele, hammoho le mesifa le litho. Khōlo ena e feteletseng e etsa hore ngoana a be moholo haholo bakeng sa lilemo tsa hae.

Matšoao a mang a kenyelletsa:

• Ho lieha ho kena bonneng kapa bosaling
• Pono e habeli kapa bothata ba pono ea lehlakore (pherekano)
• Phatla e hlahelletseng haholo (fronting bossing) le mohlahare o hlahelletseng
• Likheo lipakeng tsa meno
• Ho opeloa ke hlooho
• Ho fufuleloa ho eketsehileng
• Linako tse sa tloaelehang (ho ilela khoeli)
• Bohloko bo kopaneng
• Matsoho le maoto a maholo ka menoana le menoana e metenya
• Ho lokolloa ha lebese la matsoele
• Mathata a boroko
• Ho fifala ha litšobotsi tsa sefahleho
• Bofokoli
• Liphetoho tsa lentsoe

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao a ngoana.

Liteko tsa laboratori tse ka laeloang li kenyelletsa:

• Cortisol
• Estradiol (banana)
• Teko ea khatello ea GH
• Prolactin
• Ntho e tšoanang le kholo ea insulin-I
• Testosterone (bashanyana)
• Hormone ea qoqotho

Ho etsa liteko tsa ho etsa litšoantšo, joalo ka CT kapa MRI scan ea hlooho, le tsona li ka laeloa ho lekola hlahala ea pituitary.

Bakeng sa lihlahala tsa pituitary, ho buuoa ho ka phekola maemo a mangata.

Ha opereishene e sa khone ho tlosa hlahala ka botlalo, meriana e sebelisoa ho thibela kapa ho fokotsa ho lokolloa ha GH kapa ho thibela GH ho fihlela lisele tse lebisitsoeng.

Ka linako tse ling kalafo ea radiation e sebelisoa ho fokotsa boholo ba hlahala kamora ho buuoa.

Ho buuoa ka pituitary hangata ho atleha ho fokotsa tlhahiso ea GH.

Kalafo ea pele e ka fetola liphetoho tse ngata tse bakiloeng ke ho feta ha GH.

Phekolo ea kalafo le radiation e ka lebisa maemong a tlase a lihormone tse ling tsa pituitary. Sena se ka baka maemo a latelang:

• Ho haella ha adrenal (litšoelesa tsa adrenal ha li hlahise lihormone tsa tsona tse lekaneng)
• Lefu la tsoekere insipidus (lenyora le feteletseng le ho ntša metsi ka mokhoa o feteletseng; maemong a sa tloaelehang)
• Hypogonadism (litšoelesa tsa 'mele tsa thobalano li hlahisa lihormone tse nyane kapa ha li na tsona)
• Hypothyroidism (tšoelesa ea qoqotho ha e etse hormone ea qoqotho e lekaneng)

Bitsa mofani oa hau haeba ngoana oa hau a na le matšoao a kholo e fetelletseng.

Gigantism e ke ke ea thibeloa. Kalafo ea kapele e ka thibela lefu lena ho mpefala le ho thusa ho qoba mathata.

Pituitary seqhenqha; Tlhahiso e fetelletseng ea kholo ea hormone; Hormone ea kholo - tlhahiso e fetelletseng

• Litšoelesa tsa endocrine

Katznelson L, Melao ER Jr, Melmed S, et al; Mokhatlo oa Endocrine. Acromegaly: tataiso ea boits'oaro ba sechaba sa endocrine. J Kliniki ea Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Melmed S. Acromegaly. Ka: Jameson JL, De Groot LJ, oa Kretser DM, et al, eds. Endocrinology: Batho ba baholo le bana. La 7th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 12.