Kankere ea Endometrial
Kankere ea Endometrial ke mofetše o qalang ho endometrium, lesela la popelo (popelo).
Kankere ea Endometrial ke mofuta o tloaelehileng haholo oa mofetše oa popelo. Ha ho tsejoe hore na hantle-ntle sesosa sa mofetše oa endometrium ke eng. Tekanyo e eketsehileng ea hormone ea estrogen e ka bapala karolo. Sena se matlafatsa lera la popelo. Sena se ka lebisa ho hoholo ho sa tloaelehang ha endometrium le mofetše.
Maemong a mangata a mofets'e oa "endometrial" o hlaha pakeng tsa lilemo tse 60 le 70. Maemong a 'maloa a ka hlaha pele ho lilemo tse 40.
Lintlha tse latelang tse amanang le lihormone tsa hau li eketsa menyetla ea hau ea mofetše oa endometrium:
- Phekolo ea estrogen e sa sebelise progesterone
- Nalane ea li-polyps tsa endometrial
- Linako tse sa tloaelehang
- Le ka mohla u sa emere
- Botenya
- Lefu la tsoekere
- Lefu la Polycystic ovary (PCOS)
- Ho qala ho ilela khoeli a sa le monyane (pele ho lilemo tse 12)
- Ho qala ho khaotsa ho ilela khoeli ka mor'a lilemo tse 50
- Tamoxifen, sethethefatsi se sebelisetsoang kalafo ea mofets'e oa matsoele
Basali ba nang le maemo a latelang le bona ba bonahala ba le kotsing e kholo ea mofetše oa endometrium:
- Kankere ea Colon kapa ea matsoele
- Lefu la gallbladder
- Khatello ea mali e phahameng
Matšoao a kankere ea endometrial a kenyelletsa:
- Ho tsoa mali ka mokhoa o sa tloaelehang ka botšehaling, ho kenyelletsa ho tsoa mali lipakeng tsa ho ea matsatsing kapa ho bona / ho tsoa mali kamora ho ilela khoeli
- Likarolo tse telele haholo, tse boima kapa tse atisang ho tsoa mali ka bosaling kamora lilemo tse 40
- Mahlaba a ka mpeng a tlase kapa ho kokotloa ke noka
Nakong ea maloetse, tlhahlobo ea pelvic hangata e tloaelehile.
- Ka mekhahlelo e tsoetseng pele, ho ka ba le liphetoho ka boholo, sebopeho, kapa maikutlo a popelo kapa meaho e e potileng.
- Pap smear (e kanna ea baka lipelaelo bakeng sa mofetše oa endometrium, empa ha e e fumane)
Ho ipapisitsoe le matšoao a hau le tse ling tse fumanoeng, ho ka hlokahala liteko tse ling. Tse ling li ka etsoa ofising ea mofani oa tlhokomelo ea bophelo ba hau. Tse ling li ka etsoa sepetlele kapa setsing sa ho buoa:
- Endopsrial biopsy: Ho sebelisa catheter e nyane kapa e tšesaane (tube), lisele li nkuoa ka lera la popelo (endometrium). Lisele li hlahlojoa ka tlas'a microscope ho bona hore na ho na le tse ling tse sa tloaelehang kapa tse nang le mofetše.
- Hysteroscopy: Sesebelisoa se tšesaane se kang sebonela-hōle se kentsoe ka hara botshehadi le pulo ea molomo oa pōpelo. E lumella mofani hore a shebe bokahare ba popelo.
- Ultrasound: Ho sebelisoa maqhubu a molumo ho etsa setšoantšo sa litho tsa pelvic. The ultrasound e ka etsoa ka mpeng kapa ka botšehaling. Ultrasound e ka tseba hore na lesela la popelo le bonahala le sa tloaeleha kapa le tenya.
- Sonohysterography: Mokelikeli o kenngoa ka popelong ka pompo e tšesaane, ha litšoantšo tsa ka bosaling tsa ultrasound li entsoe ka popelo. Ts'ebetso ena e ka etsoa ho tseba boteng ba popelo efe kapa efe e sa tloaelehang eo e ka bang sesupo sa mofetše.
- Litšoantšo tsa Magnetic resonance (MRI): Tekong ena ea ho nka litšoantšo, ho sebelisoa limakete tse matla ho etsa litšoantšo tsa litho tsa kahare.
Haeba mofetše o fumanoa, ho ka etsoa liteko tsa litšoantšo ho bona hore na mofetše o nametse likarolong tse ling tsa 'mele. Sena se bitsoa sethaleng.
Mehato ea mofetše oa endometrium ke:
- Mothati oa 1: Kankere e ka popelong feela.
- Mothati oa 2: Kankere e ka popelong le molomong.
- Mothati oa 3: Kankere e hasane kantle ho popelo, empa e se hole le noka ea 'nete. Kankere e ka kenyelletsa li-lymph node ka pelvis kapa haufi le aorta (methapo e meholo ka mpeng).
- Mothati oa 4: Kankere e hasane kahare bokahare ba mala, senya, mpa kapa litho tse ling.
Kankere e boetse e hlalosoa e le sehlopheng sa 1, 2, kapa 3. Kereiti ea 1 ke eona e mabifi haholo, mme kereiti ea 3 ke e mabifi ka ho fetisisa. Ho ba mabifi ho bolela hore mofets'e o hola le ho ata kapele.
Khetho ea kalafo e kenyelletsa:
- Phekolo
- Phekolo ea radiation
- Chemotherapy
Ho buuoa ho tlosa popelo (hysterectomy) ho ka etsoa ho basali ba nang le mofets'e oa pele oa mofets'e oa pele. Ngaka e ka boela ea tlosa li-tubes le mae a bomme.
Phekolo e kopantsoeng le kalafo ea radiation ke khetho e 'ngoe ea kalafo. E sebelisoa hangata ho basali ba nang le:
- Lefu la Stage 1 le nang le monyetla o moholo oa ho khutla, le nametse ho li-lymph node, kapa ke sehlopha sa 2 kapa 3
- Boloetse ba Stage 2
Chemotherapy kapa therapy ea hormonal e ka nahaneloa maemong a mang, hangata ho ba nang le lefu la sethaleng sa 3 le sa 4.
U ka fokotsa khatello ea maikutlo ea bokuli ka ho kenela sehlopha sa ts'ehetso ea mofets'e. Ho arolelana le ba bang ba nang le liphihlelo tse tšoanang le mathata ho ka u thusa hore u se ke ua ikutloa u le mong.
Kankere ea Endometrial hangata e fumanoa e sa le qalong.
Haeba mofetše o sa namela, basali ba 95% ba ntse ba phela kamora lilemo tse 5. Haeba mofets'e o nametse lithong tse hole, basali ba ka bang 25% ba ntse ba phela kamora lilemo tse 5.
Mathata a ka kenyelletsa efe kapa efe ea tse latelang:
- Phokolo ea mali ka lebaka la tahlehelo ea mali (pele e ka fumanoa)
- Pherekano (lesoba) la popelo, le ka hlahang nakong ea D le C kapa biopsy ea endometrium
- Mathata a ho buuoa, radiation, le chemotherapy
Bitsa kopano le mofani oa hau haeba u na le tse ling tsa tse latelang:
- Ho tsoa mali kapa ho tšoaea ho hong le ho hong ho etsahalang kamora ho qala ho ilela khoeli
- Ho tsoa mali kapa ho bona makoana kamora ho etsa thobalano kapa ho robala
- Ho tsoa mali ho nka nako e telele ho feta matsatsi a 7
- Nako e sa tloaelehang ea ho ilela khoeli e etsahalang habeli ka khoeli
- Phallo e ncha kamora ho khaotsa ho ilela khoeli e qalile
- Bohloko ba 'mele kapa cramping e sa foleng
Ha ho na tlhahlobo e sebetsang ea tlhahlobo ea "cancer" ea "endometrial" (uterine).
Basali ba nang le mabaka a kotsi a kankere ea endometrium ba lokela ho lateloa haufi-ufi ke lingaka tsa bona. Sena se kenyelletsa basali ba nkang:
- Phekolo ea Estrogen e se nang kalafo ea progesterone
- Tamoxifen ka lilemo tse fetang 2
Litlhahlobo tsa khafetsa tsa pelvic, Pap smears, li-ultrasound tsa ka botšehaling le biopsy ea endometrial li ka nahaneloa maemong a mang.
Kotsi ea mofetše oa endometrial e fokotsoe ke:
- Ho boloka boima bo tloaelehileng
- Ho sebelisa lipilisi tsa thibelo ea bokhachane nako e fetang selemo
Endometrial adenocarcinoma; Popelo adenocarcinoma; Kankere ea popelo; Adenocarcinoma - endometrium; Adenocarcinoma - popelo; Kankere - popelo; Kankere - endometrial; Kankere ea uterine corpus
- Hysterectomy - mpa - ho tsoa
- Hysterectomy - laparoscopic - ho tsoa
- Hysterectomy - bosaling - ho tsoa
- Mahlaseli a 'mele - ho tsoa
- Laparoscopy ea 'mele
- Anatomy ea basali ea ho ikatisa
- D le C
- Biopsy ea Endometrium
- Hysterectomy
- Sebete
- Kankere ea Endometrial
Armstrong DK. Kankere ea mafu a basali. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 189.
Litaba tsa Boggess JF, Kilgore JE, Tran AQ. Kankere ea popelo. Ka: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, bahlophisi. Abeloff's Clinical Oncology. La 6th. Philadelphia, PA: Elsevier; 2020: khaolo ea 85.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, mofets'e oa Darai E. Endometrial. Lancet. 2016; 387 (10023): 1094-1108. PMID: 26354523 pubmed.ncbi.nlm.nih.gov/26354523/.
Webosaete ea National Cancer Institute. Phekolo ea kalafo ea mofets'e ea Endometrial (PDQ) - mofuta oa litsebi tsa bophelo bo botle. www.cancer.gov/types/uterine/hp/endometrial- kalafo-pdq. E ntlafalitsoe ka la 17 Tšitoe 2019. E fihlile ka la 24 Hlakubele 2020.
Webosaete ea National Comprehensive Cancer Network. Litaelo tsa NCCN tsa litloaelo tsa kliniki ho oncology (litataiso tsa NCCN): lihlahala tsa popelo. Mofuta oa 1.2020. www.nccn.org/professionals/physician_gls/pdf/uterine.pdf. E ntlafalitsoe ka la 6 Hlakubele 2020. E fihlile ka la 24 Hlakubele 2020.