Myelofibrosis

Myelofibrosis ke bokuli ba moko oa masapo moo moko o nkeloang sebaka ke lisele tsa 'mele tse se nang lesela.

Moko oa masapo ke lisele tse bonolo tse mafura tse ka har'a masapo a hao. Lisele tsa stem ke lisele tse sa butsoang mokong oa masapo tse fetohang lisele tsohle tsa mali. Mali a hau a entsoe ka:

• Lisele tse khubelu tsa mali (tse tsamaisang oksijene lisele tsa hau)
• Lisele tse tšoeu tsa mali (tse loantšang tšoaetso)
• Liplatelete (tse thusang mali a hau a mali)

Ha mokoallo oa masapo o tsoa mabali, o ke ke oa etsa lisele tse lekaneng tsa mali. Phokolo ea mali, mathata a ho tsoa mali, le kotsi e kholo ea tšoaetso li ka hlaha.

Ka lebaka leo, sebete le spleen li leka ho etsa tse ling tsa lisele tsena tsa mali. Sena se etsa hore litho tsena li ruruhe.

Lebaka la myelofibrosis hangata ha le tsejoe. Ha ho na lisosa tse tsejoang tsa kotsi. Ha e hlaha, hangata e hola butle ho batho ba fetang lilemo tse 50. Basali le banna ba ameha ka ho lekana. Ho na le ketsahalo e eketsehileng ea boemo bona ho Ba-Ashkenazi Bajuda.

Kankere ea mali le moko oa masapo, joalo ka myelodysplastic syndrome, leukemia le lymphoma, le eona e ka baka tšenyo ea moko oa masapo. Sena se bitsoa myelofibrosis ea bobeli.

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Botlalo ba mpa, bohloko, kapa ho ikutloa u tletse pele u qeta lijo (ka lebaka la spleen e atolositsoeng)
• Bohloko ba masapo
• Ho tsoa mali habonolo, matetetso
• Mokhathala
• Monyetla o eketsehileng oa ho fumana tšoaetso
• Letlalo le putswa
• Phefumoloho e khutšoanyane ka boikoetliso
• Ho fokotsa boima ba 'mele
• Mofufutso oa bosiu
• Feberu e tlaase
• Sebete se atolositsoeng
• Khohlela e ommeng
• Letlalo le hlohlona

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao.

Liteko tse ka etsoang li kenyelletsa:

• Palo e felletseng ea mali (CBC) e nang le smear ea mali ho lekola mefuta e fapaneng ea lisele tsa mali
• Ho lekanya tšenyo ea lisele (boemo ba enzyme ea LDH)
• Ho etsa liteko tsa lefutso
• Bops marrow biopsy ho hlahloba boemo le ho hlahloba kankere ea moko oa masapo

Ho kenya masapo a masapo kapa masapo a bakoang ho ka ntlafatsa matšoao, mme ho ka folisa lefu lena. Kalafo ena hangata e tsotelloa bacha.

Kalafo e 'ngoe e ka kenyelletsa:

• Litšelo tsa mali le meriana ho lokisa phokolo ea mali
• Mahlaseli a kotsi le chemotherapy
• Meriana e reretsoeng
• Ho tlosa spleen (splenectomy) haeba ho ruruha ho baka matšoao, kapa ho thusa ka phokolo ea mali

Ha lefu lena le ntse le mpefala, moko oa masapo o emisa ho sebetsa butle butle. Palo e tlase ea platelet e lebisa ho tsoa mali habonolo. Ho ruruha ha spleen ho ka mpefala le lefu la phokolo ea mali.

Ho pholoha ha batho ba nang le myelofibrosis ea mantlha ke lilemo tse ka bang 5. Empa batho ba bang ba phela lilemo tse mashome.

Mathata a ka kenyelletsa:

• Ntshetsopele ya a hlobaetsang le myelogenous leukemia
• Tšoaetso
• Ho tsoa mali
• Ho koala mali
• Ho hloleha ha sebete

Etsa kopano le mofani oa hau haeba u na le matšoao a lefu lena. Batla tlhokomelo ea bongaka hang-hang bakeng sa ho tsoa mali ho sa laoleheng, phefumoloho e khutšoane, kapa jaundice (letlalo le mosehla le mahlooa a masoeu) a mpefalang.

Myelofibrosis ea Idiopathic; Metaplasia ea Myeloid; Agnogenic myeloid metaplasia; Myelofibrosis ea mantlha; Myelofibrosis ea bobeli; Moko oa masapo - myelofibrosis

Gotlib J. Polycythemia vera, thrombocythemia ea bohlokoa, le myelofibrosis ea mantlha. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 157.

Nako e telele NM, Kavanagh EC. Myelofibrosis. Ka: Mopapa TL, Bloem HL, Beltran J, Morrison WB, Wilson DJ, bahlophisi. Litšoantšo tsa Musculoskeletal. Lekhetlo la bobeli. Philadelphia, PA: Elsevier Saunders; 2015: khaolo ea 76.

Mascarenhas J, Najfeld V, Kremyanskaya M, Keyzner A, Salama ME, Hoffman R. Primary myelofibrosis. Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 70.