Dysbetalipoproteinemia e tloaelehileng

Dysbetalipoproteinemia e tloaelehileng ke boloetse bo fetisoang ke malapa. E baka bongata ba k'holeseterole le triglycerides maling.

Bofokoli ba lefutso bo baka boemo bona. Bofokoli bo fella ka ho bokellana ha likaroloana tse kholo tsa lipoprotein tse nang le k'holeseterole le mofuta oa mafura a bitsoang triglycerides. Lefu lena le amahanngoa le liphoso tsa lefutso bakeng sa apolipoprotein E.

Hypothyroidism, botenya, kapa lefu la tsoekere li ka mpefatsa boemo. Lisosa tse kotsi bakeng sa dysbetalipoproteinemia ea lelapa li kenyelletsa nalane ea lelapa ea lefu lena kapa lefu la methapo ea pelo.

Matšoao a kanna a se bonahale ho fihlela a le lilemo li 20 kapa ho feta.

Mahlaseli a mosehla a mafura letlalong le bitsoang xanthomas a ka hlaha lintšing, liatleng tsa matsoho, bohatong ba maoto, kapa mesifeng ea mangole le litsoeng.

Matšoao a mang a kenyeletsa:

• Bohloko ba sefuba (angina) kapa matšoao a mang a lefu la methapo ea pelo a ka ba teng a sa le monyane
• Ho hata ka namane e le 'ngoe kapa ka bobeli ha u tsamaea
• Liso menoaneng a sa foleng
• Matšoao a tšohanyetso a kang ho otloa ke stroke joaloka ho bua ka bothata, ho theoha ka lehlakoreng le leng la sefahleho, bofokoli ba letsoho kapa leoto, le tahlehelo ea botsitso

Liteko tse ka etsoang ho fumana boemo bona li kenyelletsa:

• Ho etsa liteko tsa liphatsa tsa lefutso tsa apolipoprotein E (apoE)
• Teko ea mali ea phanele ea lipid
• Boemo ba Triglyceride
• Teko ea low density density lipoprotein (VLDL)

Morero oa kalafo ke ho laola maemo a kang botena, hypothyroidism le lefu la tsoekere.

Ho etsa liphetoho lijong ho fokotsa lik'halori, mafura a mangata, le k'holeseterole ho ka thusa ho theola k'holeseterole e maling.

Haeba maemo a k'holeseterole le triglyceride a ntse a phahame kamora ho etsa liphetoho tsa lijo, mofani oa hao oa tlhokomelo ea bophelo a kanna a u fa le meriana. Meriana ea ho theola mali triglyceride le li-cholesterol li kenyelletsa:

• Li-resin tse hlahisang acid.
• Fibrate (gemfibrozil, fenofibrate).
• Nicotinic acid.
• Lipolelo.
• PCSK9 inhibitors, joalo ka alirocumab (ea bohlokoa) le evolocumab (Repatha). Tsena li emela sehlopha se secha sa lithethefatsi ho phekola k'holeseterole.

Batho ba nang le boemo bona ba na le kotsi e eketsehang haholo ea lefu la methapo ea pelo le lefu la methapo ea pelo.

Ka kalafo, batho ba bangata ba khona ho fokotsa haholo maemo a bona a k'holeseterole le triglycerides.

Mathata a ka kenyelletsa:

• Lefu la pelo
• Leqeba
• Boloetse ba methapo ea methapo
• Tlhaloso e sa khaotseng
• Sefuba sa lipheletsong tse tlase

Bitsa mofani oa hau haeba u fumanoe u na le bothata bona mme:

• Ho hlaha matšoao a macha.
• Matšoao ha a ntlafatse kalafo.
• Matšoao a mpefala.

Ho hlahloba litho tsa malapa a batho ba nang le boemo bona ho ka lebisa tlhokomelong ea pele le kalafo.

Ho fumana kalafo kapele le ho fokotsa lisosa tse ling tse kang ho tsuba ho ka thusa ho thibela ho hlaseloa ke pelo kapele, ho otloa ke pelo le ho thibela methapo ea mali.

Mofuta oa III hyperlipoproteinemia; Apolipoprotein e haelloang kapa e haelloang E

• Boloetse ba methapo ea mali

Genest J, Libby P. Lipoprotein mathata le lefu la pelo. Ka: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Lefu la pelo la Braunwald: Buka ea bongaka ea meriana ea pelo. 11th ed. Philadelphia, PA: Elsevier; 2019: khaolo ea 48.

Robinson JG. Mathata a metabolism ea lipid. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 195.