Lefu la Klinefelter

Klinefelter syndrome ke liphatsa tsa lefutso tse hlahang ho banna ha ba e-na le chromosome ea X e eketsehileng.

Batho ba bangata ba na le li-chromosome tse 46. Li-chromosome li na le liphatsa tsa hau tsa lefutso le DNA, e leng litene tsa 'mele. Li-chromosome tsa thobalano tse 2 (X le Y) li etsa qeto ea hore na u ba moshemane kapa ngoanana. Ka tloaelo banana ba na le li-chromosome tse 2 X. Bashemane ka tloaelo ba na le chromosome e 1 X le 1 Y.

Klinefelter's syndrome e hlaha ha moshanyana a hlaha ka bonyane 1 chromosome X e eketsehileng. Sena se ngotsoe e le XXY.

Klinefelter syndrome e hlaha ho bashanyana ba ka bang 1 ho ba 500 ho isa ho ba 1 000. Basali ba emang kamora lilemo tse 35 ba na le menyetla ea ho ba le moshemane ea nang le lefu lena ho feta basali ba banyane.

Ho hloka thari ke letšoao le tloaelehileng la lefu la Klinefelter.

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Boholo ba mmele o sa tloaelehang (maoto a malelele, kutu e khuts'oane, lehetla le lekanang le boholo ba letheka)
• Matsoele a maholo ka mokhoa o sa tloaelehang (gynecomastia)
• Ho hloka thari
• Mathata a thobalano
• Moriri o ka tlase ho palo e tloaelehileng ea sephaka, sephakeng le sefahleho
• Mabele a manyane a tiileng
• Bolelele bo bolelele
• Boholo ba botona ba botona
  
  

Klinefelter syndrome e ka fumanoa pele ha monna a tla ho mofani oa tlhokomelo ea bophelo ka lebaka la ho hloka thari. Liteko tse latelang li ka etsoa:

• Karyotyping (e hlahloba li-chromosome)
• Palo ea semen

Ho tla etsoa liteko tsa mali ho lekola maemo a lihormone, ho kenyelletsa:

• Estradiol, mofuta oa estrogen
• Follicle e susumetsang li-hormone
• Hormone ea Luteinizing
• Testosterone

Phekolo ea testosterone e ka laeloa. Sena se ka thusa:

• Hōlisa moriri oa 'mele
• Ntlafatsa ponahalo ea mesifa
• Ntlafatsa mohopolo
• Ntlafatsa maikutlo le boitšepo
• Eketsa matla le ho khanna thobalano
• Eketsa matla

Banna ba bangata ba nang le lefu lena ha ba khone ho ima. Setsebi sa ho hloka thari se ka khona ho thusa. Ho bona ngaka e bitsoang endocrinologist le hona ho ka ba molemo.

Mehloli ena e ka fana ka tlhaiso-leseling e batsi ka lefu la Klinefelter:

• Mokhatlo oa Phapang ea X le Y Chromosome - genetic.org
• Laeborari ea Naha ea Bongaka, Referense ea Lehae la Liphatsa tsa lefutso - medlineplus.gov/klinefelterssyndrome.html

Meno a atolositsoeng a nang le bokaholimo bo fokolang a atile haholo ho lefu la Klinefelter. Sena se bitsoa taurodontism. Sena se ka bonoa ho x-ray ea meno.

Klinefelter's syndrome le eona e eketsa menyetla ea ho:

• Tlhokomelo e haelloang ke lefu la ho se sebetse hantle (ADHD)
• Mathata a ho itšireletsa mafung, a kang lupus, ramatiki ea lefu la masapo le lefu la Sjögren
• Kankere ea matsoele ho banna
• Ho tepella maikutlo
• Ho holofala ha ho ithuta, ho kenyelletsa le bothata ba ho bala, bo amang ho bala
• Mofuta o sa tloaelehang oa hlahala o bitsoang hlahala ea kokoana-hloko ea extragonadal
• Boloetse ba sefuba
• Lefu la ho fokola ha masapo
• Metsing ea varicose

Ikopanye le mofani oa hau haeba mora oa hau a sa hlahise litšoaneleho tsa thobalano nakong ea bocha. Sena se kenyelletsa kholo ea moriri oa sefahleho le ho teba ha lentsoe.

Moeletsi oa lefutso a ka fana ka leseli ka boemo bona mme a u tataisetsa ho ts'ehetsa lihlopha tse sebakeng sa heno.

Lefu la 47 XYY; Lefu la XXY; Trisomy ea XXY; 47, XXY / 46, XY; Lefu la mosaic; Lefu la Poly-X Klinefelter

Allan CA, McLachlan RI. Mathata a khaello ea Androgen. Ka: Jameson JL, De Groot LJ, oa Kretser DM, et al, eds. Endocrinology: Batho ba baholo le bana. La 7th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 139.

Matsumoto AM, Anawalt BD, Mathata a testicular. Ka: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, bangoli. Buka ea Williams ea Endocrinology. La bo14 la ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 19.

Nussbaum RL, McInnes RR, Willard HF. Chromosomal le genomic motheo oa lefu: mathata a li-autosomes le li-chromosomes tsa thobalano. Ka: Nussbaum RL, McInnes RR, Willard HF, bahlophisi. Thompson & Thompson liphatsa tsa lefutso tsa bongaka. La 8th. Philadelphia, PA: Elsevier; 2016: khaolo ea 6.