Tataiso e Bonolo ho Sistimi ea Endocannabinoid

Litaba

• E sebetsa joang?
• Li-Endocannabinoids
• Li-receptors tsa Endocannabinoid
• Liemahale
• Mesebetsi ea eona ke efe?
• THC e sebelisana joang le ECS?
• CBD e sebelisana joang le ECS?
• Ho thoe'ng ka khaello ea endocannabinoid?
• Ntlha ea bohlokoa

Sistimi ea endocannabinoid (ECS) ke sistimi e rarahaneng ea ho tšoaea lisele tse khethiloeng mathoasong a lilemo tsa bo-1990 ke bafuputsi ba hlahlobang THC, e leng cannabinoid e tsebahalang haholo. Li-cannabinoids ke metsoako e fumanoang ka hanf.

Litsebi li ntse li leka ho utloisisa ka botlalo ECS. Empa ho fihlela joale, rea tseba hore e bapala karolo ho laoleng mesebetsi le lits'ebetso tse fapaneng, ho kenyeletsoa:

• robala
• maikutlo
• takatso ea lijo
• mohopolo
• ho hlahisa le tsoalo

ECS e teng 'me e sebetsa' meleng oa hau leha o sa sebelise hanf.

Bala pele ho ithuta haholoanyane ka ECS ho kenyelletsa le hore na e sebetsa joang le ho sebelisana joang le kannete.

E sebetsa joang?

ECS e kenyelletsa likarolo tse tharo tsa mantlha: li-endocannabinoids, li-receptor le li-enzyme.

Li-Endocannabinoids

Endocannabinoids, eo hape e bitsoang li-cannabinoids tse sa feleng, ke limolek'hule tse entsoeng ke 'mele oa hau. Li tšoana le li-cannabinoids, empa li hlahisoa ke 'mele oa hau.

Litsebi li khethile li-endocannabinoids tse peli tsa bohlokoa ho fihlela joale:

• anandamide (AEA)
• 2-arachidonoylglyerol (2-AG)

Tsena li thusa ho boloka mesebetsi ea kahare e sebetsa hantle. 'Mele oa hau o li hlahisa kamoo ho hlokahalang, ho etsa hore ho be thata ho tseba hore na maemo a mang bakeng sa e ngoe le e ngoe ke afe.

Li-receptors tsa Endocannabinoid

Li-receptor tsena li fumaneha ho pholletsa le 'mele oa hau. Endocannabinoids e itlamme ho tsona ho bontša hore ECS e hloka ho nka bohato.

Ho na le li-receptor tse peli tsa mantlha tsa endocannabinoid:

• Li-receptor tsa CB1, tse fumanehang haholo tsamaisong ea methapo e bohareng
• Li-receptor tsa CB2, tse fumanehang haholo tsamaisong ea methapo ea hau, haholo-holo lisele tsa 'mele

Endocannabinoids e ka tlama ho amohelang. Litholoana tse hlahisoang ke sena li ipapisitse le hore na mokelikeli o hokae le hore na o ikamahanya le endocannabinoid efe.

Mohlala, endocannabinoids e kanna ea lebisa ho li-receptor tsa CB1 mokokotlong oa mokokotlo ho kokobetsa bohloko. Ba bang ba ka tlama mokelikeli oa CB2 liseleng tsa hau tsa 'mele ea ho itšireletsa mafung ho bontša hore' mele oa hau o na le ho ruruha, e leng lets'oao le tloaelehileng la mathata a boits'ireletso.

Liemahale

Li-enzyme li na le boikarabello ba ho senya li-endocannabinoids hang ha li phethile mosebetsi oa tsona.

Ho na le li-enzyme tse peli tse ka sehloohong tse ikarabellang bakeng sa sena:

• fatty acid amide hydrolase, e senyang AEA
• monoacylglycerol acid lipase, e atisang ho senya 2-AG

Mesebetsi ea eona ke efe?

ECS e thata, 'me litsebi ha li e-so tsebe hantle hore na e sebetsa joang kapa mesebetsi eohle ea eona e ka bang teng.

e hokahantse ECS le lits'ebetso tse latelang:

• takatso ea lijo le tšilo ea lijo
• metabolism
• bohloko bo sa foleng
• ho ruruha le likarabo tse ling tsa sesole sa 'mele
• maikutlo
• ho ithuta le ho hopola
• taolo ea makoloi
• robala
• ts'ebetso ea methapo ea pelo
• ho theha mesifa
• ntlafatso ea masapo le kholo
• ts'ebetso ea sebete
• mosebetsi oa tsamaiso ea ho ikatisa
• khatello ea maikutlo
• ts'ebetso ea letlalo le methapo

Mesebetsi ena kaofela e kenya letsoho ho homeostasis, e bolelang botsitso ba tikoloho ea hau ea kahare. Ka mohlala, haeba matla a kantle, a kang bohloko ba ho tsoa kotsi kapa feberu, a lahlela homeostasis ea 'mele oa hau, ECS ea hau e qala ho thusa' mele oa hau ho khutlela tšebetsong ea ona e loketseng.

Kajeno, litsebi li lumela ho boloka homeostasis haeba e le karolo ea mantlha ea ECS.

THC e sebelisana joang le ECS?

Tetrahydrocannabinol (THC) ke e 'ngoe ea li-cannabinoids tse ka sehloohong tse fumanehang ho cannabis. Ke kompone e u fang "phahameng".

Hang ha e le 'meleng oa hau, THC e sebelisana le ECS ea hau ka ho tlama li-receptor, joalo ka li-endocannabinoids. E matla ka karolo e 'ngoe hobane e ka tlamahanya le li-receptor tsa CB1 le CB2.

Sena se se lumella ho ba le litlamorao tse fapaneng 'meleng le kelellong ea hau, tse ling li lakatseha ho feta tse ling. Mohlala, cakir e ka thusa ho fokotsa bohloko mme ea u fa takatso ea lijo. Empa e ka baka paranoia le matšoenyeho maemong a mang.

Litsebi hajoale li ntse li sheba mekhoa ea ho hlahisa maiketsetso THC li-cannabinoids tse sebelisanang le ECS ka litsela tse molemo feela.

CBD e sebelisana joang le ECS?

E 'ngoe ea li-cannabinoid tse kholo tse fumanoang ka cannabis ke cannabidiol (CBD). Ho fapana le THC, CBD ha eu etse "phahameng" mme ha e bake litlamorao tse mpe.

Litsebi ha li na bonnete bo felletseng ba hore na CBD e sebelisana joang le ECS. Empa baa tseba hore ha e tlame CB1 kapa CB2 receptors ka tsela eo THC e etsang ka eona.

Sebakeng seo, ba bangata ba lumela hore e sebetsa ka ho thibela li-endocannabinoids hore li se robehe. Sena se ba lumella ho ba le tšusumetso e kholo 'meleng oa hau. Ba bang ba lumela hore CBD e tlama mokelikeli o e-s'o fumanoe.

Le ha lintlha tsa hore na li sebetsa joang li ntse li le lipuisanong, lipatlisiso li bontša hore CBD e ka thusa ka bohloko, ho nyekeloa ke pelo le matšoao a mang a amanang le maemo a mangata.

Ho thoe'ng ka khaello ea endocannabinoid?

Litsebi tse ling li lumela khopolo e tsejoang ka hore ke khaello ea bongaka ea "endocannabinoid" (CECD). Khopolo ena e fana ka maikutlo a hore maemo a tlase a endocannabinoid 'meleng oa hau kapa ho se sebetse ha ECS a ka kenya letsoho ntlafatsong ea maemo a itseng.

Ho lekola lilemo tse fetang 10 tsa lipatlisiso mabapi le taba ena ho fana ka maikutlo a hore khopolo ena e ka hlalosa hore na hobaneng batho ba bang ba ba le migraine, fibromyalgia le lefu la mala le tenang.

Ha ho le e 'ngoe ea maemo ana e nang le sesosa se hlakileng. Hape, hangata li hanana le kalafo 'me ka linako tse ling li hlaha ka thoko ho tse ling.

Haeba CECD e bapala karolo efe kapa efe maemong ana, ho lebisa tlhokomelo ho ECS kapa tlhahiso ea endocannabinoid e kanna ea ba senotlolo sa kalafo, empa lipatlisiso tse ling lia hlokahala.

Ntlha ea bohlokoa

ECS e bapala karolo e kholo ho boloka lits'ebetso tsa hau tsa kahare li tsitsitse. Empa ho ntse ho na le ho hongata hoo re sa ho tsebeng ka hona. Ha litsebi li ntse li utloisisa hantle ECS, qetellong e ka ba le senotlolo sa ho phekola maemo a 'maloa.