Sengoli: Peter Berry
Letsatsi La Creation: 12 Phupu 2021
Ntlafatsa Letsatsi: 1 December 2024
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Phekolo ea RA: DMARD le TNF-Alpha Inhibitors - Bophelo
Phekolo ea RA: DMARD le TNF-Alpha Inhibitors - Bophelo

Litaba

Selelekela

Ramatiki ea ramatiki (RA) ke lefu le sa foleng la ho itšireletsa mafung. E etsa hore sesole sa hau sa 'mele se hlasele lisele tse phetseng hantle manonyellong a hau, se bakang bohloko, ho ruruha le ho satalla. Ho fapana le osteoarthritis, e bakoang ke ho tsofala ho tloaelehileng ha u ntse u tsofala, RA e ka ama mang kapa mang ka lilemo tsohle. Ha ho motho ea tsebang hantle hore na e bakoa ke eng.

RA ha e na pheko, empa meriana e ka thusa ho kokobetsa matšoao. Meriana ena e kenyelletsa lithethefatsi tse khahlanong le ho ruruha, li-corticosteroids le lithethefatsi tse hatellang sesole sa 'mele. Tse ling tsa kalafo e sebetsang ka ho fetesisa ea lithethefatsi ke lithethefatsi tse fetolang li-anti-rheumatic drug (DMARDs), tse kenyeletsang TNF-alpha inhibitors.

Li-DMARD: Ke tsa bohlokoa kalafong ea pele

Li-DMARD ke meriana eo hangata litsebi tsa rheumatologists li fanang ka eona hang kamora ho fumanoa ke RA. Boholo ba tšenyo e kopanetsoeng ea RA e etsahalang lilemong tse peli tsa pele, ka hona meriana ena e ka ba le tšusumetso e kholo qalong ea lefu lena.

Li-DMARD li sebetsa ka ho fokolisa sesole sa hau sa 'mele. Ketso ena e fokotsa tlhaselo ea RA manonyellong a hau ho fokotsa tšenyo e akaretsang.


Mehlala ea li-DMARD e kenyelletsa:

  • methotrexate (Otrexup)
  • hydroxychloroquine (Plaquenil)
  • leflunomide (Arava)

Li-DMARD tse nang le bohloko ba bohloko

Taba e kholo ea ho sebelisa li-DMARD ke hore ba lieha ho nka khato. Ho ka nka likhoeli tse 'maloa ho utloa phomolo ea bohloko ho DMARD. Ka lebaka lena, litsebi tsa rheumatologists hangata li fana ka li-painkillers tse sebetsang ka potlako tse kang corticosteroids kapa li-nonsteroidal anti-inflammatory (NSAIDs) ho li nka ka nako e le 'ngoe. Lithethefatsi tsena li ka thusa ho fokotsa bohloko ha o ntse o emetse hore DMARD e sebetse.

Mehlala ea corticosteroids kapa li-NSAID tse ka sebelisoang le li-DMARD li kenyelletsa:

Corticosteroids

  • prednisone (Rayos)
  • methylprednisolone (Depo-Medrol)
  • triamcinolone (Aristospan)

Li-NSAID tse ka holimo ho li-counter

  • aspirin
  • ibuprofen
  • naproxen sodium

Li-NSAID tsa ngaka

  • nabumetone
  • mahlatse (mahlatse)
  • piroxicam (Feldene)

DMARD le tšoaetso

Li-DMARD li ama sesole sa hau sa 'mele. Sena se bolela hore li u beha kotsing e kholo ea tšoaetso.


Matšoao a atileng haholo ao bakuli ba RA ba nang le ona ke:

  • mafu a letlalo
  • mafu a holimo a ho hema
  • nyomonea
  • tšoaetso ea pampiri ea moroto

Ho thusa ho thibela tšoaetso, o lokela ho ikoetlisa hantle, ho kenyelletsa ho hlapa matsoho khafetsa le ho hlapa letsatsi le letsatsi kapa letsatsi le leng le le leng. Hape o lokela ho lula hole le batho ba kulang.

TNF-alpha inhibitors

Tumor necrosis factor alpha, kapa alpha ea TNF, ke ntho e hlahang ka tlhaho 'meleng oa hau. Ho RA, lisele tsa sesole sa 'mele tse hlaselang manonyeletso li theha maemo a phahameng a alffa ea TNF. Litekanyetso tsena tse phahameng li baka bohloko le ho ruruha. Le ha ho na le lintlha tse ling tse ngata tse eketsang tšenyo ea RA manonyellong, alpha ea TNF ke sebapali se ka sehloohong ts'ebetsong.

Hobane alffa ea TNF ke bothata bo boholo ho RA, TNF-alpha inhibitors ke e 'ngoe ea mefuta ea bohlokoahali ea li-DMARD' marakeng hajoale.

Ho na le mefuta e mehlano ea TNF-alpha inhibitors:

  • adalimumab (Humira)
  • etanercept (Enbrel)
  • pegol ea setifikeiti (Cimzia)
  • golimumab (Simponi)
  • infliximab (Khopotso)

Lithethefatsi tsena li boetse li bitsoa li-block block tsa TNF hobane li thibela tšebetso ea alffa ea TNF. Li fokotsa litekanyetso tsa alpha tsa TNF 'meleng oa hau ho thusa ho fokotsa matšoao a RA. Ba boetse ba qala ho sebetsa kapele ho feta li-DMARD tse ling. Li ka qala ho sebetsa nakong ea libeke tse peli ho isa ho khoeli.


Bua le ngaka ea hau

Batho ba bangata ba nang le RA ba arabela hantle ho TNF-alpha inhibitors le li-DMARD tse ling, empa ho batho ba bang, likhetho tsena li kanna tsa se sebetse ho hang. Haeba li sa u sebetse, bolella rheumatologist ea hau. Ba kanna ba fana ka TNF-alpha inhibitor e fapaneng e le mohato o latelang, kapa ba ka fana ka tlhahiso ea mofuta o fapaneng oa DMARD ka botlalo.

Etsa bonnete ba hore u nchafatsa rheumatologist ea hau ka hore na u ikutloa joang le hore na u nahana hore meriana ea hau e sebetsa hantle hakae. Hammoho, uena le ngaka ea hau le ka fumana moralo oa kalafo oa RA o tla le sebeletsa.

P:

Na lijo tsa ka li ka ama RA ea ka?

K:

Ho joalo. Ho na le lijo tse ngata tse ka thusang ho fokotsa ho ruruha 'meleng oa hau. Haeba u batla ho leka liphetoho tsa lijo ho ntlafatsa matšoao a hau a RA, qala ka ho ja lijo tse ngata tse nang le omega-3 fatty acids, li-antioxidants le fiber, joalo ka linate, tlhapi, monokotsoai, meroho le tee e tala. Tsela e 'ngoe e ntle ea ho tlisa lijo tsena ts'ebetsong ea hau ea letsatsi le letsatsi ke ho latela lijo tsa Mediterranean. Bakeng sa tlhaiso-leseling e batsi ka lijo tsena le lijo tse ling tse ka thusang ho fokotsa matšoao a RA, sheba lijo tse khahlanong le ho ruruha bakeng sa RA.

Likarabo tsa Sehlopha sa Bongaka sa Healthline Likarabo li emela maikutlo a litsebi tsa rona tsa bongaka. Likahare tsohle li na le tlhaiso-leseling ka botlalo 'me ha lia lokela ho nkuoa joalo ka likeletso tsa bongaka.

Khetho Ea Rona

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