Teko ea liphatsa tsa lefutso tsa BRAF

Litaba

• Teko ea liphatsa tsa lefutso tsa BRAF ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso tsa BRAF?
• Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BRAF?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea BRAF?
• Litšupiso

Teko ea liphatsa tsa lefutso tsa BRAF ke eng?

Teko ea liphatsa tsa lefutso ea BRAF e batla phetoho, e tsejoang e le phetoho, liphatseng tsa lefutso tse bitsoang BRAF. Liphatsa tsa lefutso ke likarolo tsa mantlha tsa lefutso tse fetisitsoeng ho tsoa ho mme le ntate oa hau.

Liphatsa tsa lefutso tsa BRAF li etsa protheine e thusang ho laola kholo ea lisele. E tsejoa e le oncogene. Oncogene e sebetsa joalo ka sethala sa khase koloing. Ka tloaelo, oncogene e fetola kholo ea sele ha ho hlokahala. Empa haeba u e-na le phetoho ea BRAF, ho tšoana le hore sethala sa khase se khomaretse, mme liphatsa tsa lefutso ha li khone ho thibela lisele ho hola. Ho hola ha sele ho sa laoleheng ho ka lebisa ho mofets'e.

Phetoho ea BRAF e ka futsetsoa ho batsoali ba hau kapa ea fumanoa hamorao bophelong. Liphetoho tse etsahalang hamorao bophelong hangata li bakoa ke tikoloho kapa ke phoso e etsahalang 'meleng oa hau nakong ea karohano ea sele. Liphetoho tse futsitsoeng tsa BRAF ha li fumanehe hangata, empa li ka baka mathata a tebileng a bophelo bo botle.

Liphetoho tsa BRAF tse fumanehang (tse tsejoang hape e le somatic) li atile haholo. Liphetoho tsena li fumanoe hoo e ka bang halofo ea batho bohle ba tšoeroeng ke kankere ea letlalo e leng melanoma. Liphetoho tsa BRAF le tsona li fumaneha khafetsa mathateng a mang le mefuta e fapaneng ea mofetše, ho kenyeletsoa mofetše oa colon, thyroid le mae a bomme. Kankere e nang le phetoho ea BRAF e atisa ho ba matla ho feta e se nang phetoho.

Mabitso a mang: BRAF tlhahlobo ea phetoho ea liphatsa tsa lefutso, Melanoma, BRAF V600 phetoho, li-cobas

E sebelisetsoa eng?

Hangata teko e sebelisoa ho batla phetoho ea BRAF ho bakuli ba melanoma kapa mefuta e meng ea mofets'e e amanang le BRAF. Meriana e meng ea mofets'e e sebetsa haholo ho batho ba nang le phetoho ea BRAF. Meriana e tšoanang ha e sebetse hantle ebile ka linako tse ling e kotsi ho batho ba se nang phetoho.

Ho etsa liteko tsa BRAF ho ka sebelisoa ho bona hore na o kotsing ea mofetše ho latela nalane ea lelapa le / kapa nalane ea bophelo ba hau.

Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso tsa BRAF?

U kanna oa hloka tlhahlobo ea BRAF haeba u fumanoe u e-na le melanoma kapa mofuta o mong oa mofetše. Ho tseba hore na o na le phetoho ho ka thusa mofani oa hau ho fana ka kalafo e nepahetseng.

U kanna ua hloka teko ena ho bona hore na u kotsing e kholo ea ho tšoaroa ke mofetše. Lisosa tsa kotsi li kenyelletsa nalane ea lelapa ea mofetše le / kapa ho ba le mofetše o sa le monyane. Nako e ikhethang e latela mofuta oa mofets'e.

Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BRAF?

Liteko tse ngata tsa BRAF li etsoa ka mokhoa o bitsoang tumor biopsy. Nakong ea biopsy, mofani oa tlhokomelo ea bophelo o tla ntša karoloana e nyane ka ho seha kapa ho hohla bokaholimo ba hlahala. Haeba mofani oa hau a hloka ho lekola lisele tsa hlahala kahare ho mmele oa hau, a ka sebelisa nale e khethehileng ho hula sampole.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Hangata ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea BRAF.

Na ho na le likotsi tsa tlhahlobo?

U kanna oa ba le maqeba kapa ho tsoa mali hanyane sebakeng sa biopsy. U kanna oa ba le bothata bo fokolang sebakeng sena bakeng sa letsatsi kapa a mabeli.

Liphetho li bolelang?

Haeba u na le melanoma kapa mofuta o mong oa mofetše, 'me liphetho li bontša hore u na le phetoho ea BRAF, mofani oa hau a ka u fa meriana e etselitsoeng ho lebisa phetoho eo. Meriana ena e ka sebetsa hantle ho feta kalafo tse ling.

Haeba u na le lefu la melanoma kapa mofuta o mong oa mofetše, 'me liphetho li u bontša seke mofetoheli oa hau o tla fana ka mefuta e fapaneng ea meriana ho alafa mofetše oa hau.

Haeba ha u e-so fumanoe u na le mofetše mme liphetho tsa hau li bontša hore u na le phetoho ea liphatsa tsa lefutso tsa BRAF, eona ha e etse joalo ho bolela hore o na le mofetše, empa o na le kotsi e kholo ea mofets'e. Empa ho hlahlojoa hangata ha mofetše, joalo ka tlhahlobo ea letlalo, ho ka fokotsa kotsi ea hau. Nakong ea tlhahlobo ea letlalo, mofani oa tlhokomelo ea bophelo o tla sheba ka hloko letlalo 'meleng oohle oa hau ho hlahloba li-moles le tse ling tse kholo tse belaetsang.

Bua le mofani oa hau ka mehato e meng eo u ka e nkang ho fokotsa kotsi ea hau.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea BRAF?

U ka utloa mofani oa hau a bua ka phetoho ea V600E. Ho na le mefuta e fapaneng ea liphetoho tsa BRAF. V600E ke mofuta o tloaelehileng haholo oa phetoho ea BRAF.

Litšupiso

1. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Kankere ea Letlalo la Melanoma; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/melanoma-skin-cancer.html
2. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Liphatsa tsa lefutso tsa onncogene le hlahala e hatellang; [e ntlafalitsoeng 2014 Jun 25; e qotsitsoeng 2018 Jul 10]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
3. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Phekolo e Reretsoeng Kankere ea Letlalo la Melanoma; [e ntlafalitsoeng 2018 Jun 28; e qotsitsoeng 2018 Jul 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
4. Kankere.Net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Ho Lekola Likotsi Tsa Kankere; 2017 Jul [e qotsitsoeng ka 2018 Phupu 10]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
5. Kankere.Net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Ho utloisisa kalafo e lebisitsoeng; 2018 Mots'eanong [e qotsitsoeng ka 2018 Phupu 10]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
6. Oncology e Kopaneng [Inthanete]. Laboratori ea Amerika; c2018. Tlhahlobo ea Phetoho ea Gene ea BRAF; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
7. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. Tlhaho; [e ntlafalitsoeng 2017 Jul 10; e qotsitsoeng 2018 Jul 10]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/glossary/biopsy
8. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. Liteko tsa lefutso bakeng sa kalafo ea mofets'e e lebisitsoeng; [e ntlafalitsoeng 2018 Jul 10; e qotsitsoeng 2018 Jul 10]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2018. ID ea Teko: BRAFT: BRAF Mutation Analysis (V600E), Hlahala: Clinical and Interpretive; [e qotsitsoeng ka 2018 Phupu 10]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
10. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Teko ea liphatsa tsa lefutso bakeng sa li-syndromes tsa mofetše oa lefutso; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
11. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: Liphatsa tsa lefutso tsa BRAF; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
12. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Kitsiso ea Kankere ea Kankere ea NCI: Phetoho ea BRAF (V600E); [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
13. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukantswe ya NCI ya Dipehelo tsa Kankere: gene; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
14. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Kankere ea Kankere ea Kankere ea NCI: oncogene; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
15. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liphatsa tsa lefutso tsa BRAF; 2018 Jul 3 [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/gene/BRAF
16. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Phetoho ea lefutso ke eng mme liphetoho li etsahala joang ?; 2018 Jul 3 [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
17. Quest Diagnostics [Inthanete]. Diagnostics ea Quest; c2000–2017. Setsi sa Teko: Melanoma, BRAF V600 Phetoho ea 'mele, Cobas: Tataiso e Fetolehang; [e qotsitsoeng ka 2018 Phupu 10]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
18. Quest Diagnostics [Inthanete]. Diagnostics ea Quest; c2000–2017. Setsi sa Teko: Melanoma, BRAF V600 Phetoho, Cobas: Kakaretso; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
19. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2018. Health Encyclopedia: Melanoma: Phekolo e Lebisitsoeng; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
20. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2018. Tlhahisoleseling mabapi le bophelo bo botle: Tlhatlhobo ea 'mele ea letlalo bakeng sa mofets'e oa letlalo. [e ntlafalitsoeng ka la 3 Mots'eanong 3; e qotsitsoeng 2018 Jul 18]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
21. Bophelo bo botle [Inthanete]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2018. Tlhahisoleseling ea Bophelo: Kankere ea Letlalo, Melanoma: Kakaretso ea Sehlooho; [e ntlafalitsoeng ka la 3 Mots'eanong 3; e qotsitsoeng 2018 Jul 10]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
22. Bophelo ba UW: Sepetlele sa Bana ba Lelapa la Amerika [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2018. Bophelo ba Bana: Biopsy; [e qotsitsoeng ka 2018 Phupu 10]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.uwhealthkids.org/kidshealth/en/parents/biopsy.html/
23. Zial J, Hui P. BRAF liteko tsa phetoho ea bongaka litloaelong tsa bongaka. Setsebi Rev Mol Diagn [Marang-rang]. 2012 Mar [e qotsitsoeng ka 2018 Phupu 10]; 12 (2): 127-38. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pubmed/22369373

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.