Boemo ba vithamine B12

Tekanyo ea vithamine B12 ke teko ea mali e lekanyang hore na vithamine B12 e kae maling a hau.

Ho hlokahala sampole ea mali.

Ha ua lokela ho ja kapa ho noa lihora tse ka bang 6 ho isa ho tse 8 pele ho tlhahlobo.

Meriana e meng e ka ama litholoana tsa tlhahlobo ena. Mofani oa hao oa tlhokomelo ea bophelo o tla u joetsa haeba ho hlokahala hore u khaotse ho noa meriana. U SE KE UA emisa moriana leha e le ofe pele u bua le mofani oa thepa ea hau.

Meriana e ka amang sephetho sa tlhahlobo e kenyelletsa:

• Colchicine
• Neomycin
• Para-aminosalicylic acid
• Phenytoin

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba ikutloa feela ho hlaba kapa ho hlaba. Kamora moo, ho ka ba le ho phatloha kapa ho longoa hanyane. Haufinyane sena sea fela.

Hangata liteko tsena li etsoa ha liteko tse ling tsa mali li fana ka maikutlo a boemo bo bitsoang megaloblastic anemia. Phokolo ea mali e matla ke mofuta oa megaloblastic anemia e bakoang ke ho monya vithamine B12 e fosahetseng. Sena se ka etsahala ha mpa e etsa lintho tse fokolang 'mele o hloka ho monya vithamine B12 hantle.

Mofani oa hau a ka boela a khothaletsa tlhahlobo ea vithamine B12 haeba u na le matšoao a itseng a methapo. Boemo bo tlase ba B12 bo ka baka ho felloa ke matla kapa ho hlohlona matsohong le maotong, bofokoli le tahlehelo ea botsitso.

Maemo a mang ao tlhahlobo e ka etsoang a kenyelletsa:

• Pherekano e matla ea tšohanyetso (delirium)
• Ho lahleheloa ke mosebetsi oa boko (dementia)
• Dementia ka lebaka la lisosa tsa metabolic
• Mathata a methapo, joalo ka pheripheral neuropathy

Litekanyetso tse tloaelehileng ke li-picograms tse 160 ho isa ho 950 ka mililitara (pg / mL), kapa li-picomoles tse 118 ho isa ho 701 ka litha e le nngwe (pmol / L).

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Labs tse ling li sebelisa litekanyo tse fapaneng kapa li kanna tsa leka mehlala e fapaneng. Bua le mofani oa hau ka seo liphetho tsa hau tsa liteko li se bolelang.

Litekanyetso tse ka tlase ho 160 pg / mL (118 pmol / L) ke sesupo sa ho haelloa ke vithamine B12. Batho ba nang le khaello ena ba kanna ba ba le kapa ba ba le matšoao.

Batho ba baholo ba nang le vithamine B12 e ka tlase ho 100 pg / mL (74 pmol / L) le bona ba ka ba le matšoao. Khaello e lokela ho netefatsoa ka ho lekola boemo ba ntho e maling e bitsoang methylmalonic acid. Boemo bo phahameng bo supa khaello ea 'nete ea B12.

Lisosa tsa khaello ea vithamine B12 li kenyelletsa:

• Ha ho na vithamine B12 e lekaneng lijong (ka seoelo, ntle le ka phepo e matla ea meroho)
• Maloetse a bakang malabsorption (mohlala, lefu la celiac le lefu la Crohn)
• Ho haella ha ntho ea bohlokoa, protheine e thusang mala ho amohela vithamine B12
• Ka holim'a tlhahiso e tloaelehileng ea mocheso (mohlala, ka hyperthyroidism)
• Boimana

Tekanyo e eketsehileng ea vithamine B12 e tloaelehile. Hangata, vithamine B12 e feteletseng e tlosoa morotong.

Maemo a ka eketsang boemo ba B12 a kenyelletsa:

• Lefu la sebete (joalo ka cirrhosis kapa hepatitis)
• Mathata a Myeloproliferative (mohlala, polycythemia vera le leukemia e sa foleng ea myelogenous)

Ha ho na kotsi e kholo ea ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho nka mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tse amanang le ho huloa mali li nyane, empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Li-punctures tse ngata ho fumana methapo
• Hematoma (mali a hahiloeng ka tlas'a letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Teko ea Cobalamin; Phokolo ea mali e matla - vithamine B12 boemo

Marcogliese AN, Yee DL. Lisebelisoa tsa hematologist: litlhaloso tse tolokang le litekanyetso tse khethiloeng tsa litšupiso bakeng sa bana ba pelehi, bana le batho ba baholo. Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 162.

Mason JB, Booth SL. Li-vithamine, sala morao liminerale le li-micronutrients tse ling. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 205.