Teko ea moroto ea 17-hydroxycorticosteroids

Teko ea 17-hydroxycorticosteroids (17-OHCS) e lekanya boemo ba 17-OHCS ka morong.

Ho hlokahala sampole ea lihora tse 24. U tla hloka ho bokella moroto oa hau ho feta lihora tse 24. Mofani oa hao oa tlhokomelo ea bophelo o tla u joetsa hore na u ka etsa sena joang. Latela litaelo hantle.

Mofani oa thepa o tla u laela, haeba ho hlokahala, ho emisa meriana e ka sitisang tlhahlobo. Tsena li ka kenyelletsa:

• Lipilisi tsa thibelo ea bokhachane tse nang le estrogen
• Meriana e meng ea lithibela-mafu
• Li-glucocorticoids

Teko e kenyelletsa feela ho ntša metsi ka mokhoa o tloaelehileng. Ha ho na bothata.

17-OHCS ke sehlahisoa se entsoeng ha sebete le lisele tse ling tsa 'mele li senya steroid hormone cortisol.

Teko ena e ka thusa ho tseba hore na 'mele o hlahisa cortisol e ngata haholo. Teko e ka sebelisoa ho fumana lefu la Cushing. Ena ke boloetse bo hlahang ha 'mele o lula o e-na le "cortisol" e phahameng khafetsa.

Molumo oa moroto le morine creatinine hangata li etsoa ka tlhahlobo ea 17-OHCS ka nako e le 'ngoe. Sena se thusa mofani hore a hlalose teko.

Teko ena ha e etsoe khafetsa hona joale. Teko ea mahala ea moroto oa cortisol ke tlhahlobo e betere ea ho hlahloba lefu la Cushing.

Litekanyetso tse tloaelehileng:

• E motona: 3 ho isa ho 9 mg / lihora tse 24 (8.3 ho isa ho 25 µmol / lihora tse 24)
• Mosali: 2 ho isa ho 8 mg / lihora tse 24 (5.5 ho isa ho 22 olmol / lihora tse 24)

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li leka liteko tse fapaneng. Bua le mofani oa hau ka moelelo oa sephetho sa hau sa liteko.

Boemo bo phahameng ho feta bo tloaelehileng ba 17-OHCS bo ka supa:

• Mofuta oa Cushing syndrome o bakoang ke hlahala ka har'a tšoelesa ea adrenal e hlahisang cortisol
• Ho tepella maikutlo
• Phekolo ea Hydrocortisone
• Khaello ea phepo e nepahetseng
• Botenya
• Boimana
• Lebaka la li-hormone la khatello e matla ea mali
• Ho imeloa kelellong le maikutlong
• Ho hlahala ho tšoelesa ea pituitary kapa kae kapa kae 'meleng e hlahisang hormone e bitsoang adrenocorticotropic hormone (ACTH)

Boemo bo tlase ho feta bo tloaelehileng ba 17-OHCS bo kanna ba supa:

• Litšoelesa tsa adrenal ha li hlahise lihormone tsa tsona tse lekaneng
• Tšoelesa ea pituitary ha e hlahise lihormone tsa eona tse lekaneng
• Khaello ea enzyme ea lefa
• Phekolo e fetileng ho tlosa tšoelesa ea adrenal

Ho rota ho feta lilithara tse 3 ka letsatsi (polyuria) ho ka etsa hore litholoana tsa tlhahlobo li be holimo leha tlhahiso ea cortisol e le ntho e tloaelehileng.

Ha ho na likotsi ka tlhahlobo ena.

Li-corticosteroids tsa 17-OH; 17-OHCS

CC ea Chernecky, Berger BJ. 17-hydroxycorticosteroids (17-OHCS) - moroto oa lihora tse 24. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 659-660.

Juszczak A, Morris DG, Grossman AB, Nieman LK. Cushing’s lefu. Ka: Jameson JL, De Groot LJ, oa Kretser DM, et al, eds. Endocrinology: Batho ba baholo le bana. La 7th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 13.