Lefu la Waterhouse-Friderichsen

Setsi sa Waterhouse-Friderichsen (WFS) ke sehlopha sa matšoao a bakoang ke ho hloleha ha litšoelesa tsa adrenal ho sebetsa ka mokhoa o tloaelehileng ka lebaka la ho tsoa mali kahara.

Litšoelesa tsa adrenal ke litšoelesa tse peli tse bopehileng joaloka likhutlo li tharo. Tšoelesa e le 'ngoe e kaholimo ho liphio ka leng. Litšoelesa tsa adrenal li hlahisa le ho lokolla lihormone tse fapaneng tseo 'mele o hlokang ho sebetsa ka mokhoa o tloaelehileng. Litšoelesa tsa adrenal li ka angoa ke mafu a mangata, joalo ka ts'oaetso e kang WFS.

WFS e bakoa ke tšoaetso e matla ea baktheria ea meningococcus kapa libaktheria tse ling tse kang:

• Streptococcus ea sehlopha B
• Pseudomonas aeruginosa
• Streptococcus pneumoniae
• Staphylococcus aureus

Matšoao a hlaha ka tšohanyetso. Li bakoa ke baktheria e holang (e ngatafalang) kahare ho mmele. Matšoao a kenyelletsa:

• Feberu le ho bata
• Bohloko bo kopaneng le ba mesifa
• Ho opeloa ke hlooho
• Ho hlatsa

Ho tšoaetsoa ke libaktheria ho baka ho tsoa mali hohle 'meleng, ho bakang:

• Lekhopho la 'mele
• E phatlalalitse coagulation ea methapo ea mali moo mali a manyane a thibelang phepelo ea mali ho litho
• Tšabo ea septic

Ho tšeloa mali ka har'a litšoelesa tsa adrenal ho baka mathata a adrenal, moo ho sa hlahisoeng lihormone tse lekaneng tsa adrenal. Sena se lebisa ho matšoao a kang:

• Botsoa, ​​bofokoli
• Khatello ea mali e tlase haholo
• Ho otla ha pelo kapele haholo
• Pherekano kapa koma

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao a motho eo.

Ho tla etsoa liteko tsa mali ho netefatsa tšoaetso ea baktheria. Liteko li ka kenyelletsa:

• Tloaelo ea mali
• Palo e felletseng ea mali ka phapang
• Lithuto tsa ho koala mali

Haeba mofani oa thepa a belaela hore ts'oaetso e bakoa ke meningococcus bacteria, liteko tse ling tse ka etsoang li kenyelletsa:

• Lumbar puncture ho fumana sampole ea mokelikeli oa mokokotlo moetlong
• Letlalo la biopsy le letheba la Gram
• Ho hlahloba moroto

Liteko tse ka laeloang ho thusa ho fumana bothata bo matla ba adrenal li kenyelletsa:

• Teko ea ho hlasimolla ea ACTH (cosyntropin)
• Teko ea mali ea Cortisol
• Tsoekere ea mali
• Teko ea mali ea potasiamo
• Teko ea mali ea sodium
• Teko ea pH ea mali

Lithibela-mafu li qalisoa hang-hang ho phekola tšoaetso ea baktheria. Meriana ea glucocorticoid e tla fuoa hape ho phekola ho se lekane ha tšoelesa ea adrenal. Phekolo e tšehetsang e tla hlokahala bakeng sa matšoao a mang.

WFS e bolaea ntle le haeba kalafo ea tšoaetso ea baktheria e qaliloe hang-hang mme lithethefatsi tsa glucocorticoid li fuoa.

Ho thibela WFS e bakoang ke baktheria ea meningococcal, vaksine ea fumaneha.

Fulminant meningococcemia - Lefu la Waterhouse-Friderichsen; Sepsis ea Fulminant meningococcal - Waterhouse-Friderichsen syndrome; Hemorrhagic adrenalitis

• Diso tsa meningococcal ka mokokotlong
• Sephiri sa adrenal gland

Stephens DS. Li-meningitides tsa Neisseria. Ka: Bennett JE, Dolin R, Blaser MJ, bahlophisi. Mandell, Douglas, le Bennett's Principles and Practice of Infectious Diseases. La 9th. Philadelphia, PA: Elsevier Saunders; 2020: khaolo ea 211.

Newell-Price JDC, Auchus RJ. Karolo ea adrenal cortex. Ka: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, bahlophisi. Buka ea Williams ea Endocrinology. La bo14 la ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 15.