Khaello ea Ntlha ea VII

Khaello ea Ntlha ea VII (supa) ke lefu le bakoang ke khaello ea protheine e bitsoang factor VII maling. E lebisa mathateng ka ho hoama ha mali (coagulation).

Ha o tsoa mali, letoto la liketso li etsahala 'meleng o thusang ho hlama ha mali. Ts'ebetso ena e bitsoa coagulation cascade. E kenyelletsa liprotheine tse khethehileng tse bitsoang coagulation, kapa li-clotting factor. U ka ba le monyetla o moholo oa ho tsoa mali a mangata haeba e le 'ngoe kapa tse ling tsa lintlha tsena li le sieo kapa li sa sebetse kamoo li lokelang ho sebetsa kateng.

Ntlha ea VII ke e 'ngoe ea li-coagulation factor. Ho haella ha factor VII ho matha ka malapeng (ho futsitsoe) mme ho sa tloaelehang haholo. Batsoali ka bobeli ba tlameha ho ba le lefutso ho fetisetsa lefu lena ho bana ba bona. Nalane ea lelapa ea lefu la ho tsoa mali e ka ba sesosa sa kotsi.

Khaello ea factor VII le eona e ka bakoa ke boemo bo bong kapa ts'ebeliso ea meriana e itseng. Sena se bitsoa khaello ea factor VII e fumanoeng. E ka bakoa ke:

• Vithamine K e tlase (bana ba bang ba tsoaloa ba na le khaello ea vithamine K)
• Lefu le matla la sebete
• Ts'ebeliso ea meriana e thibelang ho hoama (li-anticoagulants tse kang warfarin)

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Ho tsoa mali ho tsoa liseleng tsa mucus
• Ho tsoa madi manonyellong
• Ho tsoa madi ka hara mesifa
• Ho rohakana habonolo
• Ho tsoa mali haholo khoeling
• Madi a nkoang madi a sa emeng habonolo
• Mokokotlo o tsoa mali kamora ho hlaha

Liteko tse ka etsoang li kenyelletsa:

• Nako ea karoloana ea thromboplastin (PTT)
• Mosebetsi oa Plasma factor VII
• Nako ea Prothrombin (PT)
• Ho kopanya thuto, teko e khethehileng ea PTT ho netefatsa khaello ea factor VII

Ts'ollo ea mali e ka laoloa ka ho tšoaetsoa ke methapo (IV) ea mali a tloaelehileng, metsoako ea factor VII, kapa factor VII e hlahisitsoeng ka liphatsa tsa lefutso.

U tla hloka kalafo khafetsa nakong ea likarolo tse tsoang mali hobane factor VII ha e tšoarelle nako e telele kahare ho mmele. Mofuta oa factor VII o bitsoang NovoSeven le ona o ka sebelisoa.

Haeba u na le khaello ea factor VII ka lebaka la khaello ea vithamine K, u ka noa vithamine ena ka molomo, ka liente tse tlas'a letlalo, kapa ka methapo (ka methapo).

Haeba u na le bothata bona ba ho tsoa mali, etsa bonnete ba ho:

• Bolella bafani ba hao ba tlhokomelo ea bophelo pele u etsa mokhoa oa mofuta o fe kapa o fe, ho kenyeletsoa le ho buuoa le mosebetsi oa meno.
• Bolella litho tsa lelapa la hau hobane ba kanna ba ba le bothata bo tšoanang empa ha ba tsebe hona joale.

Lisebelisoa tsena li ka fana ka tlhaiso-leseling e batsi ka khaello ea Ntlha ea VII:

• Setsi sa Naha sa Haemophilia: Mefokolo e Meng ea Lintlha - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficience
• Mokhatlo oa Naha oa Mathata a Rare - rarediseases.org/rare-diseases/factor-vii-deficiency
• Referense ea Lehae la NLM Genetics - ghr.nlm.nih.gov/condition/factor-vii-deficiency

U ka lebella sephetho se setle ka kalafo e nepahetseng.

Ho haella hoa ntlha ea VII ke boemo ba bophelo bohle.

Ponahalo ea khaello ea factor VII e fumanoeng e ipapisitse le sesosa. Haeba e bakoa ke lefu la sebete, sephetho se latela hore na lefu la sebete sa hau le ka phekoloa joang. Ho noa li-supplement tsa vithamine K ho tla sebetsana le khaello ea vithamine K.

Mathata a ka kenyelletsa:

• Ho tsoa mali a mangata (hemorrhage)
• Stroke kapa mathata a mang a methapo ea methapo a tsoang mali a tsoang bohareng
• Mathata a kopaneng maemong a boima ha ho tsoa mali ho etsahala khafetsa

Fumana kalafo ea tšohanyetso hang-hang haeba u tsoa mali a mangata, a sa hlaloseheng.

Ha ho na thibelo e tsebahalang ea khaello ea factor VII e futsitsoeng. Ha khaello ea vithamine K e le sesosa, ho sebelisa vithamine K ho ka thusa.

Ho haella ha Proconvertin; Ho haella hoa factor; Serum prothrombin ho fetoha ha accelerator khaello; Lefu la Alexander

• Ho thehoa ha mali
• Ho koala mali

Gailani D, Wheeler AP, Neff AT. Mathata a sa tloaelehang a li-coagulation. Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 137.

Holo ea JE. Hemostasis le coagulation ea mali. Ka Holong ea JE, ed. Buka ea Guyton le Hall ea Physiology ea Bongaka. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 37.

Ragni MV. Mathata a hemorrhagic: ho haelloa ke lebaka la coagulation. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 174.