Lefu la Zollinger-Ellison

Zollinger-Ellison syndrome ke boemo boo 'mele o hlahisang hormone gastrin e ngata haholo. Boholo ba nako, hlahala e nyane (gastrinoma) ka har'a manyeme kapa mala a manyane ke mohloli oa gastrin e eketsehileng maling.

Zollinger-Ellison syndrome e bakoa ke lihlahala. Hangata kholo ena e fumaneha hloohong ea manyeme le mala a manyane a kaholimo. Lihlahala li bitsoa gastrinomas. Mefuta e phahameng ea gastrin e baka tlhahiso ea asiti e ngata haholo ka mpeng.

Gastrinomas e hlaha e le lihlahala tse le 'ngoe kapa lihlahala tse' maloa. Karolo e le 'ngoe ho isa ho tse tharo borarong ba gastrinomas e le' ngoe ke lihlahala tse nang le mofetše (tse kotsi). Hangata lihlahala tsena li namela sebeteng le li-lymph node tse haufi.

Batho ba bangata ba nang le gastrinomas ba na le lihlahala tse 'maloa e le karolo ea boemo bo bitsoang multiple endocrine neoplasia type I (MEN I). Lihlahala li ka hlaha lethong la pituitary (bokong) le mokokotlong oa parathyroid (molaleng) hammoho le liphakeng.

Matšoao a ka kenyelletsa:

• Bohloko ba mpeng
• Letšollo
• Ho hlatsa mali (ka linako tse ling)
• Matšoao a matla a esophageal reflux (GERD)

Matšoao a kenyelletsa liso ka mpeng le mala a manyane.

Liteko li kenyelletsa:

• Tlhaloso ea mpa ea mpa
• Teko ea infusion ea calcium
• Endoscopic ultrasound
• Ho buuoa ka lipatlisiso
• Tekanyo ea mali ea Gastrin
• Sesebelisoa sa Octreotide
• Teko ea ts'usumetso ea lekunutu

Lithethefatsi tse bitsoang proton pump inhibitors (omeprazole, lansoprazole, le tse ling) li sebelisetsoa ho phekola bothata bona. Lithethefatsi tsena li fokotsa tlhahiso ea asiti ke mpa. Sena se thusa liso ka mpeng le mala a manyane ho fola. Meriana ena e boetse e imolla bohloko ba mpeng le letshollo.

Ho buuoa ho tlosa gastrinoma e le 'ngoe ho ka etsoa haeba lihlahala li sa namela lithong tse ling. Phekolo ka mpeng (gastrectomy) ho laola tlhahiso ea acid ha e hlokehe hangata.

Palo ea pheko e tlase, leha e ka fumanoa kapele mme hlahala e tlosoa. Leha ho le joalo, gastrinomas e hola butle.Batho ba nang le boemo bona ba ka phela lilemo tse ngata kamora hore hlahala e fumanoe. Meriana e hatellang acid e sebetsa hantle ho laola matšoao.

Mathata a ka kenyelletsa:

• Ho sitoa ho fumana hlahala nakong ea ts'ebetso
• Ho tsoa mali ka mpeng kapa lesoba (pherekano) ea liso ka mpeng kapa duodenum
• Letšollo le matla le ho theola boima ba 'mele
• Ho hasana ha hlahala ho litho tse ling

Bitsa mofani oa hao oa tlhokomelo ea bophelo haeba u e-na le bohloko bo bohloko ba mpeng bo sa foleng, haholo haeba bo hlaha ka letshollo.

Lefu la Z-E; Gastrinoma

• Litšoelesa tsa endocrine

Jensen RT, Norton JA, Oberg K. Lihlahala tsa Neuroendocrine. Ka: Feldman M, Friedman LS, Brandt LJ, bahlophisi. Sleisenger le Fordtran's Mpeng le Mafu a Sebete. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 33.

Vella A. Lihormone tsa ka mpeng le lihlahala tsa endocrine. Ka: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, bahlophisi. Buka ea Williams ea Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 38.