Mantsoe a 10 ao U Lokelang ho a Tseba: Kankere ea Lung ea Lung e Nyane

Litaba

• Lenaneo la lefu-ligand 1 (PD-L1)
• Epidermal growth factor receptor (EGFR)
• Phetoho ea T790M
• Phekolo ea Tyrosinse-kinase inhibitor (TKI)
• Phetoho ea KRAS
• Phetoho ea Anaplastic lymphoma kinase (ALK)
• Adenocarcinoma
• Cellcinoma ea squamous (epidermoid) carcinoma
• Cell e kholo (e sa khetholloeng) carcinoma
• Phekolo ea Immunotherapy

Kakaretso

Ebang uena kapa moratuoa oa hau le fumanoe, kankere e seng e nyane ea kankere ea matšoafo (NSCLC) le mantsoe a mangata a amanang le eona a ka ba boima haholo. Ho leka ho boloka mantsoe ohle ao ngaka ea hau e u joetsang ona ho ka ba thata, haholoholo tlatsetsong ea maikutlo a mofets'e.

Mantsoe a 10 ke ana ao u ka kopanang le 'ona ha u ntse u feta tlhahlobo le kalafo.

Lenaneo la lefu-ligand 1 (PD-L1)

Teko ea PD-L1 e lekola ho sebetsa hantle ha liphekolo tse ling tse reretsoeng 'mele (tse atisang ho itšireletsa mafung) ho ba nang le NSCLC. Sena se thusa lingaka ho khothaletsa likhetho tse molemo ka ho fetisisa tsa kalafo ea bobeli.

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Epidermal growth factor receptor (EGFR)

EGFR ke lefutso le amehang ho hola ha sele le karohano. Liphetoho tsa lefutso lena li amana le mofetše oa matšoafo. Ho fihlela halofo ea linyeoe tsohle tsa mofetše oa matšoafo li na le phetoho ea lefutso.

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Phetoho ea T790M

T790M ke phetoho ea EGFR e bonoang hoo e ka bang halofo ea linyeoe tsohle tse hananang le lithethefatsi tsa NSCLC. Phetoho e bolela hore ho na le phetoho li-amino acid, mme e ama tsela eo motho a tla arabela kalafo ka eona.

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Phekolo ea Tyrosinse-kinase inhibitor (TKI)

Kalafo ea TKI ke mofuta oa kalafo e reretsoeng NSCLC e thibelang ts'ebetso ea EGFR, e ka bolokang lisele tsa mofetše ho hola.

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Phetoho ea KRAS

Liphatsa tsa lefutso tsa KRAS li thusa ho laola karohano ea lisele. Ke karolo ea sehlopha sa liphatsa tsa lefutso se bitsoang oncogenes. Tabeng ea phetoho, e ka fetola lisele tse phetseng hantle ho ba mofetše. Liphetoho tsa lefutso tsa KRAS li bonoa liperesente tse ka bang 15 ho isa ho 25 tsa linyeoe tsohle tsa mofetše oa matšoafo.

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Phetoho ea Anaplastic lymphoma kinase (ALK)

Phetoho ea ALK ke ho hlophisoa bocha ha mofuta oa ALK. Phetoho ena e etsahala liperesente tse ka bang 5 tsa linyeoe tsa NSCLC, haholo ho ba nang le adenocarcinoma subtype ea NSCLC. Phetoho e etsa hore lisele tsa mofetše tsa matšoafo li hole le ho hasana.

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Adenocarcinoma

Adenocarcinoma ke karoloana ea NSCLC. E atisa ho hola butle ho feta mefuta e meng ea mofetše oa matšoafo, empa sena sea fapana. Ke mofuta o tloaelehileng haholo oa mofetše oa matšoafo o bonoang ho batho ba sa tsubeng.

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Cellcinoma ea squamous (epidermoid) carcinoma

Squamous cell carcinoma ke karoloana ea NSCLC. Batho ba bangata ba nang le mofuta ona oa mofets'e oa matšoafo ba na le nalane ea ho tsuba. Kankere e qala ka lisele tse squamous, e leng lisele tse fumanehang kahare ho matšoafo.

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Cell e kholo (e sa khetholloeng) carcinoma

Cell cellcinoma e kholo ke karoloana ea NSCLC e ka hlahang karolong efe kapa efe ea matšoafo. Hangata ho ba thata ho e phekola hobane ea hola ebile e hasana kapele. E etsa karolo ea 10 ho isa ho 15 lekholong ea mofetše oa kankere.

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Phekolo ea Immunotherapy

Immunotherapy ke kalafo e ncha ea mofetše e sebelisang sesole sa 'mele sa motho ho thusa' mele ho hlasela lisele tsa mofetše. E ka sebelisoa ho alafa mefuta e meng ea NSCLC, haholo bathong bao mofets'e o khutlileng kamora chemotherapy kapa kalafo e ngoe.

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