Ubiquitin ke eng mme hobaneng e le ea bohlokoa?

Litaba

• Lisele tsa eukaryotic
• Ubiquitin e etsa eng?
• Hobaneng ha ubiquitin e le bohlokoa?
• Na ubiquitin e ka sebelisoa ho phekola maemo a mang?
• Tsela

Ubiquitin ke e nyane, 76-amino acid, protheine ea taolo e fumanoeng ka 1975. E teng liseleng tsohle tsa eukaryotic, e tataisa motsamao oa liprotheine tsa bohlokoa ka seleng, e nka karolo ho kopantseng liprotheine tse ncha le tšenyo ea liprotheine tse senyehileng.

Lisele tsa eukaryotic

E fumanoe liseleng tsohle tsa eukaryotic tse nang le tatellano e tšoanang ea amino acid, ubiquitin ha e fetohe ke phetoho. Lisele tsa eukaryotic, ho fapana le lisele tsa prokaryotic, li rarahane ebile li na le khubu le likarolo tse ling tsa ts'ebetso e ikhethang, e arotsoeng ke lera.

Lisele tsa eukaryotic li etsa limela, li-fungus le liphoofolo, ha lisele tsa prokaryotic li etsa lintho tse bonolo joalo ka libaktheria.

Ubiquitin e etsa eng?

Lisele tsa 'mele oa hau li haha ​​le ho senya liprotheine ka lebelo le potlakileng. Ubiquitin e khomarela liprotheine, e li tšoaea hore li ka lahloa. Ts'ebetso ena e bitsoa ubiquitination.

Liprotheine tse tšoailoeng li isoa liproteasomes ho senngoa. Nakoana pele protheine e kenella proteasome, ubiquitin e khaotsoe ho sebelisoa hape.

Ka 2004, Moputso oa Nobel oa Khemistri o ile oa fuoa Aaron Ciechanover, Avram Hershko le Irwin Rose bakeng sa ho sibolloa ha ts'ebetso ena, e bitsoang ubiquitin mediated degradation (proteolysis).

Hobaneng ha ubiquitin e le bohlokoa?

Ho ipapisitsoe le ts'ebetso ea eona, ubiquitin e ithutiloe bakeng sa karolo ea kalafo e ka reretsoeng ho alafa mofetše.

Lingaka li shebana le litšitiso tse ikhethang liseleng tsa mofetše tse li lumellang ho phela. Morero ke ho sebelisa ubiquitin ho laola protheine e liseleng tsa mofetše ho etsa hore sele ea mofetše e shoe.

Phuputso ea ubiquitin e lebisitse ho nts'etsopele ea li-inhibitor tse tharo tse amoheloang ke Tsamaiso ea Lijo le Lithethefatsi (FDA) ho phekola batho ba nang le myeloma e mengata, mofuta oa mofets'e oa mali:

• bortezomib (Velcade)
• carfilzomib (Kyprolis)
• ixazomib (Ninlaro)

Na ubiquitin e ka sebelisoa ho phekola maemo a mang?

Ho ea ka Setsi sa Kankere ea Naha, bafuputsi ba ntse ba ithuta ubiquitin kamanong le mmele o tloaelehileng, lefu la pelo, methapo, mofetše le mathata a mang. Ba shebile lintlha tse 'maloa tsa ubiquitin, ho kenyelletsa:

• ho laola pholoho le lefu la lisele tsa mofetše
• kamano ea eona le khatello ea maikutlo
• Karolo ea eona mitochondria le se boleloang ke lefu lena

Liphuputso tse 'maloa tsa morao-rao li batlisitse ts'ebeliso ea ubiquitin merianeng ea lisele:

• Tlhahiso ea hore ubiquitin e boetse e kenella lits'ebetsong tse ling tsa cellular, joalo ka ts'ebetso ea karabelo ea ho ruruha ea nyutlelie-κB (NF-κB) le tokiso ea tšenyo ea DNA.
• Tlhahiso ea hore ho se sebetse ha sistimi ea ubiquitin ho ka lebisa ho mathata a methapo le mafu a mang a batho. Phuputso ena e boetse e bonts'a hore sistimi ea ubiquitin e kentse letsoho ho nts'etsopele ea mafu a ho ruruha le ho itšireletsa mafung, joalo ka ramatiki le psoriasis.
• Tlhahiso ea hore livaerase tse ngata, ho kenyeletsoa le ntaramane A (IAV), li theha ts'oaetso ka ho nka ubiquitination.

Leha ho le joalo, ka lebaka la tlhaho ea eona e fapaneng le e rarahaneng, mekhoa ea liketso tsa 'mele le pathophysiological tsa sistimi ea ubiquitin ha e e-so utloisisoe ka botlalo.

Tsela

Ubiquitin e bapala karolo ea bohlokoa ho laoleng protheine maemong a lisele. Lingaka li lumela hore e na le monyetla o ts'episang oa mefuta e fapaneng ea kalafo ea meriana ea lisele.

Phuputso ea ubiquitin e se e lebisitse ho nts'etsopele ea meriana ea kalafo ea myeloma e mengata, mofuta oa mofets'e oa mali. Meriana ena e kenyelletsa bortezomib (Velcade), carfilzomib (Kyprolis), le ixazomib (Ninlaro).