Polyarteritis nodosa

Polyarteritis nodosa ke lefu le tebileng la methapo ea mali. Mothapo o monyane le o mahareng o a ruruha ebe oa senyeha.

Metsing ke methapo ea mali e tsamaisang mali a nang le oksijene ho litho le lisele. Lebaka la polyarteritis nodosa ha le tsejoe. Boemo bo etsahala ha lisele tse ling tsa 'mele tsa ho itšireletsa mafung li hlasela methapo e amehileng. Lisele tse fepeloang ke methapo e amehileng ha li fumane oksijene le phepo e hlokahalang. Tšenyo e ba teng ka lebaka leo.

Batho ba baholo ho feta bana ba tšoaroa ke lefu lena.

Batho ba nang le lefu la sebete la mofuta oa B kapa la hepatitis C ba ka ba le lefu lena.

Matšoao a bakoa ke tšenyo ea litho tse amehileng. Letlalo, manonyeletso, mesifa, pampitšana ea meno, pelo, liphio le tsamaiso ea methapo hangata lia ameha.

Matšoao a kenyelletsa:

• Bohloko ba mpeng
• Ho fokotsa takatso ea lijo
• Mokhathala
• Feberu
• Mahlaba a kopaneng
• Bohloko ba mesifa
• Ho theola boima ba 'mele ka boomo
• Bofokoli

Haeba methapo e ameha, u ka ba le ho ba shoohlo, bohloko, ho cha le ho fokola. Tšenyo ea tsamaiso ea methapo e ka baka likotlo kapa ho oa.

Ha ho liteko tse khethehileng tsa laboratori tse fumanehang ho fumana polyarteritis nodosa. Ho na le mathata a 'maloa a nang le likarolo tse tšoanang le polyarthritis nodosa. Tsena li tsejoa e le "baetsisi."

U tla ba le tlhahlobo e felletseng ea 'mele.

Liteko tsa Lab tse ka thusang ho etsa hore lefu lena le fumanoe le ho laoloa ke mefuta e kenyeletsa:

• Palo e felletseng ea mali (CBC) e nang le phapang, creatinine, liteko tsa hepatitis B le C, le ho hlahlojoa ha urinalysis
• Sekhahla sa sedryation sa Erythrocyte (ESR) kapa C-reactive protein (CRP)
• Serum protheine electrophoresis, cryoglobulins
• Maemo a tlatsetso ea Serum
• Arteriogram
• Biopsy ea lisele
• Liteko tse ling tsa mali li tla etsoa ho hlakola maemo a ts'oanang, joalo ka systemic lupus erythematosus (ANA) kapa granulomatosis le polyangiitis (ANCA)
• Teko ea HIV
• Li-cryoglobulins
• Li-antibodies tsa anti-phospholipid
• Litso tsa mali

Kalafo e kenyelletsa meriana e hatellang ho ruruha le sesole sa 'mele. Tsena li ka kenyelletsa li-steroid, joalo ka prednisone. Meriana e ts'oanang, joalo ka azathioprine, methotrexate kapa mycophenolate e lumellang ho fokotsa lethal dose ea li-steroid le eona e sebelisoa hangata. Cyclophosphamide e sebelisoa maemong a boima.

Bakeng sa polyarteritis nodosa e amanang le lefu la sebete, kalafo e ka kenyelletsa plasmapheresis le meriana e thibelang likokoana-hloko.

Kalafo ea hajoale e nang le li-steroid le lithethefatsi tse ling tse hatellang sesole sa 'mele (joalo ka azathioprine kapa cyclophosphamide) li ka ntlafatsa matšoao le monyetla oa ho phela nako e telele.

Mathata a tebileng haholo hangata a kenyelletsa liphio le pampiri ea meno.

Ntle le kalafo, pono e mpe.

Mathata a ka kenyelletsa:

• Lefu la pelo
• Necrosis ea mala le pherekano
• Ho hloleha ha liphio
• Leqeba

Bitsa mofani oa tlhokomelo ea bophelo haeba u ba le matšoao a lefu lena. Ho fumanoa esale pele le kalafo ho ka ntlafatsa menyetla ea sephetho se setle.

Ha ho na thibelo e tsebahalang. Leha ho le joalo, kalafo ea kapele e ka thibela tšenyo le matšoao.

Periarteritis nodosa; PAN; Sesebelisoa sa necrotizing vasculitis

• Microscopic polyarteritis 2
• Tsamaiso ea potoloho ea mali

Luqmani R, Awisat A. Polyarteritis nodosa le mathata a amanang le ona. Ka: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, bahlophisi. Firestein & Kelley's Textbook ea Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021: khaolo ea 95.

Puéchal X, Pagnoux C, Baron G, le al. Ho eketsa azathioprine ho remission-induction glucocorticoids bakeng sa eosinophilic granulomatosis le polyangiitis (Churg-Strauss), microscopic polyangiitis, kapa polyarteritis nodosa ntle le mabaka a mabe: teko e sa laoleheng, e laoloang. Ramatiki Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

Shanmugam VK. Vasculitis le li-arteriopathies tse ling tse sa tloaelehang. Ka: Sidawy AN, Perler BA, bahlophisi. Rutherford's Vasculry and Endovascular Therapy. La 9th. Philadelphia, PA: Elsevier; 2019: khaolo ea 137.

Lejoe JH. Tsamaiso ea vasculitides. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 254.