Phekolo ea Hormone bakeng sa mofetše oa matsoele

Phekolo ea Hormone ho phekola mofetše oa matsoele e sebelisa lithethefatsi kapa kalafo ho theola maemo kapa ho thibela ts'ebetso ea lihormone tsa basali tsa bong (estrogen le progesterone) 'meleng oa mosali. Sena se thusa ho liehisa kholo ea mefuta e mengata ea mofetše oa matsoele.

Phekolo ea Hormone e etsa hore mofets'e o se ke oa khutla kamora ho buuoa ke mofetše oa matsoele. E boetse e fokotsa kholo ea mofets'e oa matsoele o nametseng likarolong tse ling tsa 'mele.

Phekolo ea Hormone e ka sebelisoa ho thusa ho thibela mofetše ho basali ba kotsing e kholo ea mofetše oa matsoele.

E fapane le kalafo ea lihormone ho alafa matšoao a ho khaotsa ho ilela khoeli.

Lihomone tsa estrogen le progesterone li etsa hore mefuta e meng ea kankere ea matsoele e hōle. Li bitsoa kankere ea matsoele e mamelang li-hormone. Bongata ba mofetše oa matsoele bo nahanela lihormone.

Estrogen le progesterone li hlahisoa ka mae a bomme le lisele tse ling tse kang mafura le letlalo. Ka mor'a ho khaotsa ho ilela khoeli, mae a bomme a khaotsa ho hlahisa lihomone tsena. Empa 'mele o ntse o tsoela pele ho etsa palo e nyane.

Phekolo ea Hormone e sebetsa feela ho mofets'e o utloang lihormone. Ho bona hore na kalafo ea lihormone e ka sebetsa, lingaka li leka sampole ea hlahala e tlositsoeng nakong ea opereishene ho bona hore na mofetše o kanna oa utloa lihormone.

Phekolo ea Hormone e ka sebetsa ka litsela tse peli:

• Ka ho thibela estrogen ho sebetsa liseleng tsa mofetše
• Ka ho theola maemo a estrogen ’meleng oa mosali

Lithethefatsi tse ling li sebetsa ka ho thibela estrogen hore e se ke ea baka lisele tsa mofetše.

Tamoxifen (Nolvadex) ke sethethefatsi se thibelang estrogen ho bolella lisele tsa mofetše ho hola. E na le melemo e 'maloa:

• Ho nka Tamoxifen ka lilemo tse 5 kamora ho buuoa ka mofetše oa matsoele ho fokotsa menyetla ea mofets'e ho khutla ka halofo. Boithuto bo bong bo bontša hore ho e nka lilemo tse 10 ho ka sebetsa le ho feta.
• E fokotsa kotsi ea hore mofetše o ka hola letsoeleng le leng.
• E fokotsa kholo mme e nyenyefatsa mofetše o nameng.
• E fokotsa menyetla ea ho tšoaroa ke mofetše ho basali ba kotsing e kholo.

Lithethefatsi tse ling tse sebetsang ka tsela e ts'oanang li sebelisoa ho alafa mofetše o tsoetseng pele o namileng:

• Toremifene (Fareston)
• Fulvestrant (Faslodex)

Lithethefatsi tse ling, tse bitsoang aromatase inhibitors (AI), li emisa 'mele ho etsa estrogen liseleng tse kang mafura le letlalo. Empa, lithethefatsi tsena ha li sebetse ho etsa hore mae a bomme a khaotse ho etsa estrogen. Ka lebaka lena, li sebelisoa haholo ho theola maemo a estrogen ho basali ba fetileng nakong ea ho ilela khoeli (postmenopausal). Mae a bomme ha a sa etsa estrogen.

Basali ba premenopausal ba ka nka li-AI haeba le bona ba noa lithethefatsi tse emisang mae a bomme ho etsa estrogen.

Aromatase inhibitors e kenyelletsa:

• Anastrozole (Arimidex)
• Letrozole (Femara)
• Exemestane (Aromasin)

Mofuta ona oa kalafo o sebetsa feela ho basali ba premenopausal ba nang le mae a bomme a sebetsang. E ka thusa mefuta e meng ea kalafo ea lihormone hore e sebetse hantle. E boetse e sebelisetsoa ho alafa mofetše o namileng.

Ho na le mekhoa e meraro ea ho theola maemo a estrogen ho tsoa mae a bomme:

• Ho buoa ho tlosa mae a bomme
• Mahlaseli a kotsi a senya mae a bomme ka hona ha a sa sebetsa, e leng a sa feleng
• Lithethefatsi tse kang goserelin (Zoladex) le leuprolide (Lupron) tse emisang mae a bomme nakoana ho etsa estrogen

E 'ngoe ea mekhoa ena e tla kenya mosali nakong ea ho khaotsa ho ilela khoeli. Sena se baka matšoao a ho khaotsa ho ilela khoeli:

• Ho chesa haholo
• Mofufutso oa bosiu
• Ho omella ha botshehadi
• Feto-fetoha
• Ho tepella maikutlo
• Ho felloa ke thahasello liphate

Litla-morao tsa kalafo ea lihormone li ipapisitse le sethethefatsi. Litla-morao tse tloaelehileng li kenyelletsa mahlaseli a chesang, ho fufuleloa bosiu le ho omella ka botšehaling.

Lithethefatsi tse ling li ka baka litla-morao tse sa tloaelehang, empa tse tebileng joalo ka:

• Tamoxifen. Ho koala mali, ho otloa ke lefu la pelo, lera la mahlo, mofetše oa endometrium le oa popelo, ho feto-fetoha ha maikutlo, khatello ea maikutlo le ho felloa ke thahasello litabeng tsa thobalano.
• Aromatase inhibitors. Cholesterol e phahameng, tlhaselo ea pelo, ho senyeha ha masapo, bohloko ba manonyeletso, ho fetoha ha maikutlo le khatello ea maikutlo.
• Mohlokomeli. Ho felloa ke takatso ea lijo, ho nyekeloa ke pelo, ho hlatsa, ho sokela, letshollo, bohloko ba mpeng, bofokoli le bohloko.

Ho etsa qeto ea kalafo ea li-hormone bakeng sa mofetše oa matsoele e ka ba qeto e thata ebile e thata. Mofuta oa kalafo eo u e fumanang o kanna oa itšetleha ka hore na o fetile nako ea ho ilela khoeli pele ho kalafo ea mofets'e. Hape ho kanna ha itšetleha ka hore na o batla ho ba le bana. Ho bua le mofani oa tlhokomelo ea bophelo ka likhetho tsa hau le melemo le likotsi tsa kalafo e ngoe le e ngoe ho ka u thusa ho etsa qeto e molemohali bakeng sa hau.

Phekolo ea Hormonal - kankere ea matsoele; Kalafo ea Hormone - kankere ea matsoele; Phekolo ea Endocrine; Kankere e mamelang Hormone - kalafo; Phekolo e ntle ea ER; Aromatase inhibitors - kankere ea matsoele

Webosaete ea American Cancer Society. Phekolo ea Hormone bakeng sa mofetše oa matsoele. www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. E ntlafalitsoe ka Loetse 18, 2019. E fihlile ka la 11 Pulungoana.

Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS. Kankere ea letsoele. Ka: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, bahlophisi. Abeloff's Clinical Oncology. La 6th. Philadelphia, PA: Elsevier; 2020: khaolo ea 88.

Webosaete ea National Cancer Institute. Phekolo ea Hormone bakeng sa mofetše oa matsoele. www.cancer.gov/types/breast/breast-hormone-therapy-fact-sheet. E ntlafalitsoe ka la 14 Hlakola 2017. E fihlile ka la 11 Pulungoana, 2019.

Rugo HS, Rumble RB, Macrae E, le al. Phekolo ea Endocrine bakeng sa kankere ea matsoele e amohelang li-hormone receptor-positive: American Society of Clinical Oncology Guideline. Kliniki ea Oncol. 2016; 34 (25): 3069-3103. PMID: 27217461 www.ncbi.nlm.nih.gov/pubmed/27217461.

• Kankere ea matsoele